Sensorimotor gating deficits in adults with autism

被引:268
|
作者
Perry, William
Minassian, Arpi
Lopez, Brian
Maron, Leeza
Lincoln, Alan
机构
[1] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
[2] Univ New Mexico, Ctr Dev & Disabil, Dept Pediat, Albuquerque, NM 87131 USA
[3] Ctr Autism Res Evaluat & Serv, San Diego, CA USA
关键词
autistic disorder; executive functioning; fluency; prepulse inhibition; sensorimotor gating; startle;
D O I
10.1016/j.biopsych.2005.09.025
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Prepulse inhibition (PPI) is an operational measure of sensorimotor gating and is impaired in a family of neuropsychiatric disorders characterized by abnormalities of inhibitory function. Adults with autistic disorder (AD) exhibit clinical features of inhibitory deficits, such as restrictive and repetitive behaviors, that may be explained by deficits in sensorimotor gating. Methods: Acoustic startle reactivity, habituation, and PPI (30-, 60-, 120-msec interstimulus intervals) were assessed in 14 adult men diagnosed with AD and 16 typically developing normal comparison (NC) participants. All participants were administered measures of intelligence and frontal-executive functioning. Results: Adults with AD exhibited significantly less PPI in the 60-msec condition than NC participants, which was correlated with increased ratings of restricted and repetitive behaviors. The groups did not differ on measures of startle amplitude or overall,effect. Furthermore, PPI was not related to intelligence but habituation. There was, however, a significant group-by-block habituation effect was moderately associated with performance on a measure of frontal-executive functioning. Conclusions. Adults with AD have sensorimotor gating deficits similar to other neurodevelopmental disorders, implicating a failure of normal inhibitory regulation of sensory motor. and attentional mechanisms. thus, PPI deficits may be indirectly linked to one of the ballmark features of AD.
引用
收藏
页码:482 / 486
页数:5
相关论文
共 50 条
  • [21] Sensorimotor gating deficits in rodent developmental models related to psychotic disorders
    Geyer, M
    Powell, SB
    NEUROPSYCHOPHARMACOLOGY, 2005, 30 : S8 - S8
  • [22] Sensorimotor gating deficits in obsessive compulsive disorder (OCD): Lateralized findings
    Swerdlow, NR
    Hartston, HJ
    Zinner, S
    BIOLOGICAL PSYCHIATRY, 1997, 41 : 284 - 284
  • [23] Is dopamine to blame for CRF-induced sensorimotor gating deficits in rats?
    Hammer, RP
    Arrillaga-Romany, IC
    NEUROPSYCHOPHARMACOLOGY, 2005, 30 : S44 - S44
  • [24] Clonidine Normalizes Sensorimotor Gating Deficits in Patients With Schizophrenia on Stable Medication
    Oranje, Bob
    Glenthoj, Birte Y.
    SCHIZOPHRENIA BULLETIN, 2013, 39 (03) : 684 - 691
  • [25] Effects of acute treatment with antidepressant drugs on sensorimotor gating deficits in rats
    Pouzet, B
    Andersen, MP
    Hogg, S
    PSYCHOPHARMACOLOGY, 2005, 178 (01) : 9 - 16
  • [26] Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats
    Bakshi, VP
    Geyer, MA
    PHYSIOLOGY & BEHAVIOR, 1999, 67 (03) : 385 - 392
  • [27] Examination of ketamine-induced deficits in sensorimotor gating and spatial learning
    Sabbagh, Jonathan J.
    Heaney, Chelcie F.
    Bolton, Monica M.
    Murtishaw, Andrew S.
    Kinney, Jefferson W.
    PHYSIOLOGY & BEHAVIOR, 2012, 107 (03) : 355 - 363
  • [28] Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania
    Perry, W
    Minassian, A
    Feifel, D
    Braff, DL
    BIOLOGICAL PSYCHIATRY, 2001, 50 (06) : 418 - 424
  • [29] CLOZAPINE AND HALOPERIDOL IN AN ANIMAL-MODEL OF SENSORIMOTOR GATING DEFICITS IN SCHIZOPHRENIA
    SWERDLOW, NR
    GEYER, MA
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1993, 44 (03) : 741 - 744
  • [30] Glutamate effects on schizophrenia-like sensorimotor gating deficits in rodents
    Geyer, MA
    Bakshi, VP
    Swerdlow, NR
    BIOLOGICAL PSYCHIATRY, 1997, 41 : 1 - 1