Transport of Oligonucleotides Into HL-60 Cells Using Nanocellulose

Currently, biodegradable, nontoxic, biocompatible drug carriers are in demand. Nanocellulose obtained by mechanical attrition is capable of forming multiple hydrogen bonds, which allows it to form complexes with potential drugs. We have shown that a complex of oligonucleotides with nanocellulose as a carrier penetrates into HL-60 cancer cells, resulting in an increase in their cytotoxicity. The spectroscopic data also show that the nanocellulose-fluorescent dye complex penetrates into the cytoplasm of HL-60 cells. Our results show that nanocellulose can be used as a carrier for anticancer drugs, as well as an optical label for tissue and intracellular processes.