ABEMACICLIB, A SELECTIVE CDK4/6 INHIBITOR, RESTRICTS GROWTH OF PEDIATRIC GLIAL-LINEAGE TUMORS IN VITRO AND IN VIVO

被引：0
|
作者：
Liang, Muh-Lii [1 ]
Hsieh, Tsung-Han [2 ]
Wong, Tai-Tong [3 ]
机构：
[1] Mackay Mem Hosp, Dept Neurosurg, Taipei, Taiwan
[2] Taipei Med Univ, Off Human Res, Joint Biobank, Taipei, Taiwan
[3] Taipei Med Univ Hosp, Dept Neurosurg, Taipei, Taiwan
来源：
NEURO-ONCOLOGY | 2020年 / 22卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MODL-16
引用
收藏
页码：414 / 414
页数：1
相关论文
共 50 条
  • [21] Abemaciclib, a CDK4 and 6 inhibitor with unique pharmacological properties for breast cancer therapy.
    Torres-Guzman, Raquel
    Ganado, Maria Patricia
    Perez, Cecila Mur
    Marugan, Carlos
    Baquero, Carmen
    Yang, Yanzhu
    Du, Jian
    de Dios, Alfonso
    Puig, Oscar
    Lallena, Maria Jose
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [22] The CDK4/CDK6 inhibitor abemaciclib inhibits transcriptional targets which facilitate growth in ER plus breast cancer cells
    McNulty, Ann M.
    Burke, Teresa
    Dempsey, Jack A.
    Marchal, Christophe C.
    Schade, Andrew E.
    Szpurka, Hadrian P.
    Dowless, Michele S.
    Stephens, Jennifer
    Stephens, Jennifer
    Edmondson, Denise
    Stayrook, Keith
    Caldwell, William C.
    Buchanan, Sean
    Merzoug, Farhana F.
    Beckmann, Richard P.
    MOLECULAR CANCER RESEARCH, 2016, 14
  • [23] Combination CDK4/6 inhibition and AR agonism suppresses the growth of CDK4/6 inhibitor resistant breast cancers
    Freelander, Allegra
    Laven-Law, Geraldine
    Eshraghi, Leila
    Chia, Kee Ming
    Pickering, Marie
    Yong, Aliza
    Wilkinson, Ashleigh
    Alexandrou, Sarah
    Caldon, C. Elizabeth
    Hickey, Theresa E.
    Tilley, Wayne D.
    Lim, Elgene
    CANCER RESEARCH, 2022, 82 (04)
  • [24] An UHPLC-MS/MS method for quantification of the CDK4/6 inhibitor abemaciclib in human serum
    Habler, Katharina
    Vogeser, Michael
    Teupser, Daniel
    JOURNAL OF MASS SPECTROMETRY AND ADVANCES IN THE CLINICAL LAB, 2022, 24 : 15 - 21
  • [25] Molecular mechanism of vacuolar formation associated with cell death induced by CDK4/6 inhibitor abemaciclib
    Hino, Hirotsugu
    Tanaka, Yoshinori
    Okimoto, Tomoya
    Ikeda, Toshikatsu
    Hara, Tomoyo
    Takeya, Kosuke
    Takano, Naoharu
    Hiramoto, Masaka
    Aizawa, Shin
    Miyazawa, Keisuke
    Eto, Masumi
    Hirai, Shuichi
    CANCER SCIENCE, 2025, 116 : 1741 - 1741
  • [26] Abemaciclib (CDK4/6 Inhibitor) Blockade Induces Cytotoxicity in Human Anaplastic Thyroid Carcinoma Cells
    Abutorabi, Elaheh Seyed
    Irani, Shiva
    Yaghmaie, Marjan
    Ghaffari, Seyed Hamid
    REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2020, 8 (04): : 438 - 445
  • [27] Cell death induction in resting lymphocytes by pan-Cdk inhibitor, but not by Cdk4/6 selective inhibitor
    Kobayashi, Makiko
    Takahashi-Suzuki, Ikuko
    Shimomura, Toshiyasu
    Iwasawa, Yoshikazu
    Hirai, Hiroshi
    INVESTIGATIONAL NEW DRUGS, 2011, 29 (05) : 921 - 931
  • [28] Cell death induction in resting lymphocytes by pan-Cdk inhibitor, but not by Cdk4/6 selective inhibitor
    Makiko Kobayashi
    Ikuko Takahashi-Suzuki
    Toshiyasu Shimomura
    Yoshikazu Iwasawa
    Hiroshi Hirai
    Investigational New Drugs, 2011, 29 : 921 - 931
  • [29] FCN-437: A novel, potent and selective oral inhibitor of CDK4/6 for the treatment of solid tumors
    Lin, Shu
    Zhao, Xingdong
    Li, Tongshuang
    Zhang, Huajie
    Tan, Haohan
    Wang, Xianlong
    Jiang, Lihua
    Liu, Yanxin
    Sun, Jing
    Li Linghu
    Liu, Qihong
    Li, Zhifu
    Zhang, Weipeng
    Wang, Weibo
    CANCER RESEARCH, 2019, 79 (13)
  • [30] Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors
    Patnaik, Amita
    Rosen, Lee S.
    Tolaney, Sara M.
    Tolcher, Anthony W.
    Goldman, Jonathan W.
    Gandhi, Leena
    Papadopoulos, Kyriakos P.
    Beeram, Muralidhar
    Rasco, Drew W.
    Hilton, John F.
    Nasir, Aejaz
    Beckmann, Richard P.
    Schade, Andrew E.
    Fulford, Angie D.
    Nguyen, Tuan S.
    Martinez, Ricardo
    Kulanthaivel, Palaniappan
    Li, Lily Q.
    Frenzel, Martin
    Cronier, Damien M.
    Chan, Edward M.
    Flaherty, Keith T.
    Wen, Patrick Y.
    Shapiro, Geoffrey I.
    CANCER DISCOVERY, 2016, 6 (07) : 740 - 753
12345