Therapeutic effect of blood reinfusions and intravenous injections of opiates antagonists in experimental hemorrhagic shock.

Acute experiments on 82 adult rabbits aimed at elucidation of effects of opiate antagonists and blood reinfusions in hemorrhagic shock (HS) demonstrate that injection of 0.5 mg/kg and 2.0 mg/kg of nalorphine or 0.1 mg/kg of naloxone affects negatively HS duration and outcome. Blood reinfusion in the latest period of shock increases survival of the animals. Injection of nalorphine under hemodynamic action of blood reinfusion increases the survival, the benefit being more pronounced for the dose 2.0 mg/kg. The injection of naloxone after the reinfusion had no effect on the outcomes.