Sibutramine: its mode of action and efficacy

被引：52
|
作者：
Finer, N [1 ]
机构：
[1] Addenbrookes Hosp, Clin Res Facil, Cambridge CB2 2QQ, England
来源：
INTERNATIONAL JOURNAL OF OBESITY | 2002年 / 26卷 / Suppl 4期
关键词：
sibutramine; mechanism of action; weight loss; predictors of success;
D O I：
10.1038/sj.ijo.0802216
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sibutramine has a dual mode of action. It reduces food intake and attenuates the fall in metabolic rate associated with weight loss. The drug's neurochemical actions can also be distinguished from those of previous centrally acting anti-obesity agents. Clinical trials show that two out of three patients taking sibutramine lose greater than or equal to 5% weight and that the drug can enhance the maintenance of weight loss. Early weight loss predicts long-term success and can be used to guide clinical practice. To maximize the benefits of sibutramine, it is important that patients receive adjunctive diet and lifestyle therapy.
引用
收藏
页码：S29 / S33
页数：5
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