Controlled release of drug molecules in metal-organic framework material HKUST-1

被引：60

作者：

Chen, Qing ^{[1
,3
]}

Chen, Qi-Wei ^{[1
,3
]}

Zhuang, Chong ^{[1
,3
]}

Tang, Piao-Ping ^{[2
]}

Lin, Ning ^{[1
,3
]}

Wei, Lian-Qiang ^{[2
]}

机构：

[1] Guangxi Univ Chinese Med, Coll Pharm, Nanning 530001, Peoples R China

[2] Hechi Univ, Coll Chem & Bioengn, Yizhou 546300, Peoples R China

[3] Guangxi Zhuang Yao Med Ctr Engn & Technol, Nanning 530200, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2017年 / 79卷

基金：

中国国家自然科学基金;

关键词：

Metal organic frameworks; HKUST-1; Drug delivery; Controlled release; ADSORPTION; COMPLEXES; LIGAND; MOF;

D O I：

10.1016/j.inoche.2017.03.027

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The Cu-3(BTC)(2) metal-organic framework (MOF) (BTC 1,3,5-benzenetricarboxylate), also known as HKUST-1, is one of the earliest reported stable MOFs with a very high surface area. In this study, HKUST-1 was used for the first time to absorb the pharmaceutical products of ibuprofen, anethole and guaiacol with loading amount of 034 g.g(-1), 038 g.g(-1) and 0.40 g.g(-1), respectively, which also showing good controlled drug release property. The result from this work provides a new attempt for HKUST-1 to be used as potential platform for drug delivery and release. (C) 2017 Published by Elsevier B.V.

引用

页码：78 / 81

页数：4

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