Two New 5-Oxomilbemycins Possessing an Unusual 3,27-Epoxy Bond from the Genetically Engineered Strain Streptomyces bingchenggensis BCJ60

被引：2
|
作者：
Hao, Zhi-Kui [1 ]
Li, Jian-Song [1 ]
Wang, Ji-Dong [2 ]
Xiang, Wen-Sheng [3 ]
Wang, Hai-Yan [3 ]
机构：
[1] Taizhou Vocat & Tech Coll, Inst Appl Biotechnol, Sch Med & Pharmaceut Engn, Taizhou 318000, Peoples R China
[2] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China
[3] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin 150000, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2021年 / 57卷 / 02期
关键词：
genetically engineered strain; Streptomyces bingchenggensis BCJ60; milbemycin derivatives; acaricidal and nematocidal activities;
D O I：
10.1007/s10600-021-03339-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two undescribed milbemycin derivatives, milbemycin P (1) and milbemycin Q (2), were isolated from a culture of the genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with previous reports. Their acaricidal and nematocidal activities against Tetranychus cinnabarinus and Bursaphelenchus xylophilus were tested. The results showed that compounds 1-2 possessed potent acaricidal and nematocidal activities.
引用
收藏
页码：289 / 292
页数：4
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