Melanoma-associated retinopathy versus abnormal retinal function due to interferon-α/isotretinoin therapy in cutaneous malignant melanoma

被引:8
|
作者
Feigl, B
Faschinger, C
Soyer, P
机构
[1] Graz Univ, Dept Ophthalmol, Augenklin, A-8036 Graz, Austria
[2] Graz Univ, Dept Dermatol, A-8036 Graz, Austria
关键词
melanoma-associated retinopathy; isotretinoin-associated retinopathy; interferon-associated retinopathy;
D O I
10.1159/000027503
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To analyze whether an abnormal retinal function in patients with a cutaneous malignant melanoma was due to paraneoplastic retinopathy or due to isotretinoin or interferon-alpha. Methods: We studied 15 patients with malignant melanoma in stage IIa and IIb who are all participants in a randomized, multicentered, double-blind placebo-controlled clinical trial comparing interferon-alpha/isotretinoin versus interferon-alpha/placebo performed by the Department of Dermatology, University of Graz. Our assessment included a full ophthalmic history and examination, electrophysiological testing (ERG, EGG), dark adaption, color vision and visual field testing. Results: The most prevalent ocular symptom patients complained about was ocular dryness (8 patients). Electro physiological as well as psychophysical testings showed no abnormalities in 12 patients. In 1 patient the therapy was stopped because of electrophysiological and psychophysiological pathology. This patient suffered from severe reduction of night vision and visual disturbances. Another patient had had night blindness since childhood which remained stable. Conclusions: We postulate that in 1 of 15 patients, visual complaints are caused with a high probability by melanoma-associated retinopathy although, in the literature, isotretinoin is described to show similar effects on retinal function. Copyright (C) 2000 S. Karger AG, Basel.
引用
收藏
页码:271 / 276
页数:6
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