The VP3 Protein of Bluetongue Virus Associates with the MAVS Complex and Interferes with the RIG-I-Signaling Pathway

被引：8

作者：

Pourcelot, Marie ^{[1
]}

Amaral Moraes, Rayane ^{[1
]}

Fablet, Aurore ^{[1
]}

Breard, Emmanuel ^{[1
]}

Sailleau, Corinne ^{[1
]}

Viarouge, Cyril ^{[1
]}

Postic, Lydie ^{[1
]}

Zientara, Stephan ^{[1
]}

Caignard, Gregory ^{[1
]}

Vitour, Damien ^{[1
]}

机构：

[1] Univ Paris Est, Ecole Natl Vet Alfort, ANSES, Dept Anim,UMR 1161,Virol,Lab Anim Hlth,INRAE, F-94700 Maisons Alfort, France

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 02期

关键词：

Bluetongue virus; VP3; MAVS; IKKε type-I interferons; virus– host interactions;

D O I：

10.3390/v13020230

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bluetongue virus (BTV), an arbovirus transmitted by Culicoides biting midges, is a major concern of wild and domestic ruminants. While BTV induces type I interferon (alpha/beta interferon [IFN-alpha/beta]) production in infected cells, several reports have described evasion strategies elaborated by this virus to dampen this intrinsic, innate response. In the present study, we suggest that BTV VP3 is a new viral antagonist of the IFN-beta synthesis. Indeed, using split luciferase and coprecipitation assays, we report an interaction between VP3 and both the mitochondrial adapter protein MAVS and the IRF3-kinase IKK epsilon. Overall, this study describes a putative role for the BTV structural protein VP3 in the control of the antiviral response.

引用

页数：10

共 47 条

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