The VP3 Protein of Bluetongue Virus Associates with the MAVS Complex and Interferes with the RIG-I-Signaling Pathway

被引：8

作者：

Pourcelot, Marie ^{[1
]}

Amaral Moraes, Rayane ^{[1
]}

Fablet, Aurore ^{[1
]}

Breard, Emmanuel ^{[1
]}

Sailleau, Corinne ^{[1
]}

Viarouge, Cyril ^{[1
]}

Postic, Lydie ^{[1
]}

Zientara, Stephan ^{[1
]}

Caignard, Gregory ^{[1
]}

Vitour, Damien ^{[1
]}

机构：

[1] Univ Paris Est, Ecole Natl Vet Alfort, ANSES, Dept Anim,UMR 1161,Virol,Lab Anim Hlth,INRAE, F-94700 Maisons Alfort, France

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 02期

关键词：

Bluetongue virus; VP3; MAVS; IKKε type-I interferons; virus– host interactions;

D O I：

10.3390/v13020230

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bluetongue virus (BTV), an arbovirus transmitted by Culicoides biting midges, is a major concern of wild and domestic ruminants. While BTV induces type I interferon (alpha/beta interferon [IFN-alpha/beta]) production in infected cells, several reports have described evasion strategies elaborated by this virus to dampen this intrinsic, innate response. In the present study, we suggest that BTV VP3 is a new viral antagonist of the IFN-beta synthesis. Indeed, using split luciferase and coprecipitation assays, we report an interaction between VP3 and both the mitochondrial adapter protein MAVS and the IRF3-kinase IKK epsilon. Overall, this study describes a putative role for the BTV structural protein VP3 in the control of the antiviral response.

引用

页数：10

共 47 条

[1] Mapping the assembly pathway of Bluetongue virus scaffolding protein VP3
Kar, AK
Ghosh, M
Roy, P
VIROLOGY, 2004, 324 (02) : 387 - 399
[2] Encephalomyocarditis Virus Structural Protein VP3 Interacts with MAVS and Promotes its Autophagic Degradation to Interfere with the Type I Interferon Signaling Pathway
Zhao, Xu
Hou, Zhengyang
Zhang, Yaxin
Mao, Daoqin
Yan, Zhenfang
Yang, Shunyu
Xie, Jingying
Feng, Ruofei
FRONTIERS IN BIOSCIENCE-LANDMARK, 2024, 29 (07):
[3] Assembly and intracellular localization of the bluetongue virus core protein VP3
Kar, AK
Iwatani, N
Roy, P
JOURNAL OF VIROLOGY, 2005, 79 (17) : 11487 - 11495
[4] The structural protein VP3 of enterovirus D68 interacts with MAVS to inhibit the NF-κB signaling pathway
Chen, Honghua
Huang, Mengqian
Hou, Bei
Liu, Zixiang
Tan, Ruyang
Cui, Luna
Wang, Tao
Wang, Zhiyun
JOURNAL OF VIROLOGY, 2025,
[5] Inhibition of MAVS Aggregation-Mediated Type-I Interferon Signaling by Foot-and-Mouth Disease Virus VP3
Ekanayaka, Pathum
Lee, Byeong-Hoon
Weerawardhana, Asela
Chathuranga, Kiramage
Park, Jong-Hyeon
Lee, Jong-Soo
VIRUSES-BASEL, 2021, 13 (09):
[6] The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-β signaling pathway
Li, Dan
Yang, Wenping
Yang, Fan
Liu, Huanan
Zhu, Zixiang
Lian, Kaiqi
Lei, Caoqi
Li, Shu
Liu, Xiangtao
Zheng, Haixue
Shu, Hongbing
FASEB JOURNAL, 2016, 30 (05): : 1757 - 1766
[7] Synthesis of bluetongue virus chimeric VP3 molecules and their interactions with VP7 protein to assemble into virus core-like particles
Tanaka, S
Mikhailov, M
Roy, P
VIROLOGY, 1995, 214 (02) : 593 - 601
[8] Hepatitis A virus VP3 protein activates serum response element associated signaling pathway in HeLa cells.
Kanda, T
Yokosuka, O
Fujiwara, K
Saisho, H
Kato, N
Omata, M
HEPATOLOGY, 2001, 34 (04) : 486A - 486A
[9] SYNTHESIS AND CHARACTERIZATION OF CHIMERIC PARTICLES BETWEEN EPIZOOTIC HEMORRHAGIC-DISEASE VIRUS AND BLUETONGUE VIRUS - FUNCTIONAL DOMAINS ARE CONSERVED ON THE VP3 PROTEIN
LEBLOIS, H
FAYARD, B
URAKAWA, T
ROY, P
JOURNAL OF VIROLOGY, 1991, 65 (09) : 4821 - 4831
[10] GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS
Chen, Zihong
Benureau, Yann
Rijnbrand, Rene
Yi, Jianzhong
Wang, Ting
Warter, Lucile
Lanford, Robert E.
Weinman, Steven A.
Lemon, Stanley M.
Martin, Annette
Li, Kui
JOURNAL OF VIROLOGY, 2007, 81 (02) : 964 - 976

← 1 2 3 4 5 →