Effects of chronic chrysin treatment in spontaneously hypertensive rats

被引：65
|
作者：
Villar, IC [1 ]
Jiménez, R [1 ]
Galisteo, M [1 ]
Garcia-Saura, MF [1 ]
Zarzuelo, A [1 ]
Duarte, J [1 ]
机构：
[1] Univ Granada, Sch Pharm, Dept Pharmacol, Granada 18071, Spain
来源：
PLANTA MEDICA | 2002年 / 68卷 / 09期
关键词：
D O I：
10.1055/s-2002-34400
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The effects of an oral daily dose (20 mg kg(-1)) of the flavonoid chrysin for 6 weeks in spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) were analysed. Chrysin reduces SHR elevated blood pressure, cardiac hypertrophy and functional vascular changes, but is without effect in WKY. These protective effects were associated with a reduced oxidative status due to the antioxidant properties of the drug.
引用
收藏
页码：847 / 850
页数：4
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