O-Methyl-bis-O-(4-nitrophenyl)phosphite: a novel chemoselective O-phosphitylating reagent

被引：1
|
作者：
Dabkowski, Wojciech [1 ]
Kazimierczak, Lucja [1 ]
机构：
[1] Polish Acad Sci, Ctr Mol & Macromol Studies, PL-90363 Lodz, Poland
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 35期
关键词：
PHOSPHORAMIDITE METHOD; NUCLEOTIDE SYNTHESIS; ACTIVATING REAGENT; DEOXYNUCLEOSIDE PHOSPHORAMIDITES; OLIGONUCLEOTIDES; PHOSPHITES; CHEMISTRY; ANALOGS; 2,4-DINITROPHENOL; PROMOTER;
D O I：
10.1016/j.tetlet.2009.06.102
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel chemoselective O-phosphitylating reagent containing two aryloxy leaving groups at a P(III) center is developed for selective formation of P(Ill) esters from amino alcohols without the need to protect the amino group. The reagent proved to be highly convenient for the synthesis of dinucleotides, P(III)-F structures, and cyclic P(III) nucleotides. (C) 2009 Elsevier Ltd. All rights reserved.
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页码：5035 / 5039
页数：5
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