Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants

被引：10
|
作者：
Yerkovich, Stephanie T.
Rowe, Julie
Richmond, Peter
Suriyaarachchi, Devinda
Heaton, Tricia
Hollams, Elysia
Ladyman, Claire
Serralha, Michael
Sadowska, Agata
Loh, Richard
Wesselingh, Steven L.
Sly, Peter D.
Holt, Patrick G.
机构：
[1] Univ Western Australia, Telethon Inst Child Hlth Res, Perth, WA 6009, Australia
[2] Univ Western Australia, Fac Med & Dent, Ctr Child Hlth Res, Perth, WA 6009, Australia
[3] Univ Western Australia, Dept Paediat, Perth, WA 6009, Australia
[4] Princess Margaret Hosp Children, Dept Clin Immunol, Subiaco, WA, Australia
[5] Macfarlane Burnet Inst Med Res & Publ Hlth, Melbourne, Vic, Australia
来源：
VACCINE | 2007年 / 25卷 / 10期
关键词：
MMR; cytokines; infants;
D O I：
10.1016/j.vaccine.2006.11.022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study compared the potency and immunomodulatory effects of measles mumps rubella (MMR) vaccine given to infants alone or in combination with varicella (MMR and V). In an additional group, NIMR vaccination was delayed 42 days to permit analysis of potential effects on underlying maturation of systemic immune functions. Assessment of immunity to the vaccines indicated consistent antibody production coupled with mixed Th1/Th2 memory, and no significant differences between vaccine groups or to the group who had their MMR vaccination delayed. Parallel analyses of cytokine responses to phytohaemagglutinin and tetanus toxoid did not detect any "bystander" effects of the vaccines on systemic immunity. (c) 2006 Elsevier Ltd. All rights reserved.
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页码：1764 / 1770
页数：7
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