The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

被引：13

作者：

De Simone, Belinda ^{[1
]}

Abu-Zidan, Fikri M. ^{[2
,3
]}

Chouillard, Elie ^{[1
]}

Di Saverio, Salomone ^{[4
]}

Sartelli, Massimo ^{[5
]}

Podda, Mauro ^{[6
]}

Gomes, Carlos Augusto ^{[7
]}

Moore, Ernest E. ^{[8
]}

Moug, Susan J. ^{[9
]}

Ansaloni, Luca ^{[10
]}

Kluger, Yoram ^{[11
]}

Coccolini, Federico ^{[12
]}

Landaluce-Olavarria, Aitor ^{[13
]}

Estraviz-Mateos, Begona ^{[13
]}

Uriguen-Etxeberria, Ana ^{[13
]}

Giordano, Alessio ^{[14
]}

Luna, Alfonso Palmieri ^{[15
]}

Amin, Luz Adriana Hernandez ^{[15
]}

Hernandez, Adriana Maria Palmieri ^{[15
]}

Shabana, Amanda ^{[16
]}

Dzulkarnaen, Zakaria Andee ^{[17
]}

Othman, Muhammad Asyraf ^{[17
]}

Sani, Mohamad Ikhwan ^{[17
]}

Balla, Andrea ^{[18
]}

Scaramuzzo, Rosa ^{[18
]}

Lepiane, Pasquale ^{[18
]}

Bottari, Andrea ^{[19
]}

Staderini, Fabio ^{[19
]}

Cianchi, Fabio ^{[19
]}

Cavallaro, Andrea ^{[20
]}

Zanghi, Antonio ^{[20
]}

Cappellani, Alessandro ^{[20
]}

Campagnacci, Roberto ^{[21
]}

Maurizi, Angela ^{[21
]}

Martinotti, Mario ^{[22
]}

Ruggieri, Annamaria ^{[22
]}

Jusoh, Asri Che ^{[23
]}

Rahman, Karim Abdul ^{[23
]}

Zulkifli, Anis Suraya M. ^{[23
]}

Petronio, Barbara ^{[24
]}

Matias-Garcia, Belen ^{[25
]}

Quiroga-Valcarcel, Ana ^{[25
]}

Mendoza-Moreno, Fernando ^{[25
]}

Atanasov, Boyko ^{[26
]}

Campanile, Fabio Cesare ^{[27
]}

Vecchioni, Ilaria ^{[27
]}

Cardinali, Luca ^{[28
]}

Travaglini, Grazia ^{[28
]}

Sebastiani, Elisa ^{[28
]}

Chooklin, Serge ^{[29
]}

机构：

[1] Poissy & St Germain Laye Hosp, Dept Emergency Digest & Metab Minimally Invas Sur, Poissy, France

[2] United Arab Emirates Univ, Coll Med & Hlth Sci, Res Off, Al Ain, U Arab Emirates

[3] United Arab Emirates Univ, Al Ain, U Arab Emirates

[4] Santa Maria del Soccorso Hosp, Dept Gen Surg, San Benedetto Tronto, Ascoli Piceno, Italy

[5] Macerata Hosp, Dept Gen Surg, Macerata, Italy

[6] Univ Cagliari, Dept Surg Sci, Cagliari, Italy

[7] Hosp Univ Terezinha Jesus SUPREMA, Fac Ciencia Med & Saude Juiz de Fora, Juiz De Fora, Brazil

[8] Denver Hlth, Ernest E Moore Shock Trauma Ctr, Denver, CO USA

[9] Univ Glasgow, Royal Alexandra Hosp, Paisley & Golden Jubilee Natl Hosp, Dept Surg, Glasgow, Lanark, Scotland

[10] Univ Hosp Pavia, Dept Gen Surg, Pavia, Italy

[11] Rambam Acad Hosp, Dept Gen Surg, Haifa, Israel

[12] Univ Hosp Pisa, Dept Gen & Emergency Surg, Pisa, Italy

[13] Alfredo Espinosa Urduliz Hosp, Urduliz, Spain

[14] Santo Stefano Hosp, Gen Surg Unit, ASL Toscana Ctr, Prato, Italy

[15] Univ Sucre, Clin Santa Maria, Sincelejo, Colombia

[16] John Radcliffe Hosp, Emergency Surg Dept, Oxford, England

[17] Univ Sains Malaysia, Sch Med Sci & Hosp USM, Dept Surg, Kubang Kerian, Kelantan, Malaysia

[18] Hosp San Paolo, UOC Gen & Minimally Invas Surg, Largo Donatori Sangue 1, I-00053 Rome, Italy

[19] AOU Careggi, SOD Chirurg Apparat Digerente, Florence, Italy

[20] Univ Catania, Policlin G Rodolico San Marco Hosp, Dept Surg, Catania, Italy

[21] Carlo Urbani Hosp, UOC Gen Surg, Jesi, AN, Italy

[22] Hosp Ist Citta Pavia, Pavia, Italy

[23] Hosp Sultan Ismail Petra, Dept Gen Surg, Kuala Krai 18000, Kelantan, Malaysia

[24] San Polo Monfalcone, Chirurg Gen & Mininvas, Monfalcone, GO, Italy

[25] Hosp Univ Principe Asturias, Alcala De Henares, Spain

[26] Med Univ Plovdiv, UMHAT Eurohosp, RIMU, Plovdiv, Bulgaria

[27] Osped San Giovanni Decollato Andosilla ASL, Civita Castellana, Viterbo, VT, Italy

[28] Osped Madonna del Soccorso, UOC Chirurg Gen, San Benedetto Tronto, Italy

[29] Lviv Reg Clin Hosp, Lvov, Ukraine

[30] Lorenzo Bonomo Hosp, ASL BAT, Andria, Puglia, Italy

[31] Univ Magna Graecia Med Sch, Mater Domini Hosp, Sci Hlth Dept, Gen Surg Unit, Viale Europa, I-88100 Catanzaro, Italy

[32] Hosp Virgen del Rocio, Emergency Surg Unit, Seville, Spain

[33] Univ Clin Ctr Tuzla, Clin Surg, Tuzla, Bosnia & Herceg

[34] Santa Croce & Carle Hosp, Cuneo, Italy

[35] AOU Citta Salute & Sci, Chirurg Gen Urgenza & PS, Turin, Italy

[36] ASMN IRCCS REGGIO EMILIA, Gen & Emergency Surg, Reggio Emilia, Italy

[37] Univ Padua, Reg Hosp Treviso, DISCOG, Surg Unit 2, Treviso, Italy

[38] Osped San Valentino, UO Chirurg Gen & Urgenza, Treviso, Italy

[39] AUSL Piacenza, Dept Surg, G Da Saliceto Hosp, Piacenza, Italy

[40] Tzaneio Gen Hosp, Dept Surg 3, Styliani Aikaterini Vederaki, Piraeus, Greece

[41] Private Ortadogu Hosp, Clin Surg, Adana, Turkey

[42] Private Medline Hosp, Clin Radiol, Adana, Turkey

[43] Kestel State Hosp, Dept Gen Surg, Bursa, Turkey

[44] Univ Hlth Sci, Bagcilar Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey

[45] Koc Univ, Fac Med, Gen Surg Dept, Istanbul, Turkey

[46] Kavala Gen Hosp, Dept Surg 1, Kavala, Greece

[47] Azienda Osped Univ Ferrara, Dipartimento Chirurg, Arcispedale St Anna, UO Chirurg 1, Ferrara, Italy

[48] Sakarya Training & Res Hosp, Sakarya, Turkey

[49] Lavagna Hosp, Dept Gen Surg ASL 4, Genoa, Italy

[50] Univ Samsun, Samsun Training & Res Hosp, Samsun, Turkey

来源：

WORLD JOURNAL OF EMERGENCY SURGERY | 2022年 / 17卷 / 01期

关键词：

Acute cholecystitis; Cholecystectomy; Gangrene; COVID-19; SARS-CoV-2; Laparoscopy; Surgery; Pandemic; Gangrenous cholecystitis; CHOLECYSTECTOMY; GUIDELINES; MORTALITY;

D O I：

10.1186/s13017-022-00466-4

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

BackgroundThe incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not.MethodsData were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not.ResultsA total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p=0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001].ConclusionsThe incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.

引用

页数：16

共 50 条

[11] BIO-MECHANICS OF ARDS IN COVID-19: A PROSPECTIVE OBSERVATIONAL STUDY
Naeem, Ehsun
Ionescu, Filip
Imam, Zaid
Castillo, Edward
Ayala, Enrique Calvo
Dogra, Sanjay
Patel, Vishal
Mina, Nader
Keena, Daniel
Dalal, Bhavinkumar
Dado, Christopher
Adam, Abdulgadir
Grasso-Knight, Giovi
Bozyk, Paul
Nair, Girish
CHEST, 2020, 158 (04) : 298A - 299A
[12] TRANSCRANIAL DOPPLER FINDINGS IN PATIENTS WITH COVID-19: PROSPECTIVE OBSERVATIONAL STUDY
Santos, M.
Andrade, J.
Silveira, A. F.
Martins, H.
Rocha, E.
Moulin De Moraes, F.
Silva, G.
INTERNATIONAL JOURNAL OF STROKE, 2024, 19 (02) : 495 - 495
[13] TREATMENT OF COVID-19 WITH REMDESIVIR AND CONVALESCENT PLASMA: A PROSPECTIVE, OBSERVATIONAL STUDY
Gyanwali, Pradip
Dhimal, Meghnath
Bhattarai, Saroj
Nepal, Bipin
Manandhar, Rekha
Jha, Runa
Adhikari, Prabhat
Panthi, Chhabi Lal
Bista, Bihungum
Pant, Suman
Karki, Shristi
Koirala, Janak
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2021, 105 (05): : 290 - 290
[14] A Prospective Observational Study of Prevalence of Asymptomatic COVID-19 Patients in Vietnam
Duc, Tran Quang
Huyen, Do Thu
Huong, Nguyen Thi Thanh
Huyen, Nguyen Thi Hoa
Quang, Phan Ngoc
Chi, Vu Thi Quynh
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH, 2022, 34 (6-7) : 705 - 707
[15] Does Vaping Increase Susceptibility to COVID-19?
Sharma, Pawan
Zeki, Amir A.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 202 (07) : 1055 - 1056
[16] Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)
Siriwardena, Ajith K.
Calini, Giacomo
BJS OPEN, 2022, 6 (03):
[17] Impact of COVID-19 infection on the dialysis population prospective, observational, nationwide study
Ali AlSahow
Ahmed AlQallaf
Anas AlYousef
Hamad Bahbahani
Yousif Bahbahani
Bassam AlHelal
Heba AlRajab
Abdullah AlMuhaiteeb
Heba Shalaby
Mohamed Elabbadi
Mohammad Elsebaei
Emad Abdallah
Medhat Ayoub
Aissar AbouTrabeh
Maryam AlSarrajji
Abdullah AlAwadhi
Rajeev Kumar
International Urology and Nephrology, 2023, 55 : 721 - 727
[18] Pain Manifestations of COVID-19 and Their Association With Mortality: A Multicenter Prospective Observational Study
Knox, Nigel
Lee, Chang-Soon
Moon, Jee Youn
Cohen, Steven P.
MAYO CLINIC PROCEEDINGS, 2021, 96 (04) : 943 - 951
[19] Lung ultrasound in predicting COVID-19 clinical outcomes: A prospective observational study
Chardoli, Mojtaba
Sabbaghan Kermani, Shaghayegh
Abdollahzade Manqoutaei, Sanaz
Loesche, Michael A.
Duggan, Nicole M.
Schulwolf, Sara
Tofighi, Rojin
Yadegari, Sina
Shokoohi, Hamid
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN, 2021, 2 (06)
[20] Malnutrition is associated with hyperinflammation and immunosuppression in COVID-19 patients: A prospective observational study
Liu, Heng
Zhou, Liang
Wang, Hugen
Wang, Xiaobo
Qu, Guangbo
Cai, Jing
Zhang, Hong
NUTRITION IN CLINICAL PRACTICE, 2021, 36 (04) : 863 - 871

← 1 2 3 4 5 →