The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

被引：13

作者：

De Simone, Belinda ^{[1
]}

Abu-Zidan, Fikri M. ^{[2
,3
]}

Chouillard, Elie ^{[1
]}

Di Saverio, Salomone ^{[4
]}

Sartelli, Massimo ^{[5
]}

Podda, Mauro ^{[6
]}

Gomes, Carlos Augusto ^{[7
]}

Moore, Ernest E. ^{[8
]}

Moug, Susan J. ^{[9
]}

Ansaloni, Luca ^{[10
]}

Kluger, Yoram ^{[11
]}

Coccolini, Federico ^{[12
]}

Landaluce-Olavarria, Aitor ^{[13
]}

Estraviz-Mateos, Begona ^{[13
]}

Uriguen-Etxeberria, Ana ^{[13
]}

Giordano, Alessio ^{[14
]}

Luna, Alfonso Palmieri ^{[15
]}

Amin, Luz Adriana Hernandez ^{[15
]}

Hernandez, Adriana Maria Palmieri ^{[15
]}

Shabana, Amanda ^{[16
]}

Dzulkarnaen, Zakaria Andee ^{[17
]}

Othman, Muhammad Asyraf ^{[17
]}

Sani, Mohamad Ikhwan ^{[17
]}

Balla, Andrea ^{[18
]}

Scaramuzzo, Rosa ^{[18
]}

Lepiane, Pasquale ^{[18
]}

Bottari, Andrea ^{[19
]}

Staderini, Fabio ^{[19
]}

Cianchi, Fabio ^{[19
]}

Cavallaro, Andrea ^{[20
]}

Zanghi, Antonio ^{[20
]}

Cappellani, Alessandro ^{[20
]}

Campagnacci, Roberto ^{[21
]}

Maurizi, Angela ^{[21
]}

Martinotti, Mario ^{[22
]}

Ruggieri, Annamaria ^{[22
]}

Jusoh, Asri Che ^{[23
]}

Rahman, Karim Abdul ^{[23
]}

Zulkifli, Anis Suraya M. ^{[23
]}

Petronio, Barbara ^{[24
]}

Matias-Garcia, Belen ^{[25
]}

Quiroga-Valcarcel, Ana ^{[25
]}

Mendoza-Moreno, Fernando ^{[25
]}

Atanasov, Boyko ^{[26
]}

Campanile, Fabio Cesare ^{[27
]}

Vecchioni, Ilaria ^{[27
]}

Cardinali, Luca ^{[28
]}

Travaglini, Grazia ^{[28
]}

Sebastiani, Elisa ^{[28
]}

Chooklin, Serge ^{[29
]}

机构：

[1] Poissy & St Germain Laye Hosp, Dept Emergency Digest & Metab Minimally Invas Sur, Poissy, France

[2] United Arab Emirates Univ, Coll Med & Hlth Sci, Res Off, Al Ain, U Arab Emirates

[3] United Arab Emirates Univ, Al Ain, U Arab Emirates

[4] Santa Maria del Soccorso Hosp, Dept Gen Surg, San Benedetto Tronto, Ascoli Piceno, Italy

[5] Macerata Hosp, Dept Gen Surg, Macerata, Italy

[6] Univ Cagliari, Dept Surg Sci, Cagliari, Italy

[7] Hosp Univ Terezinha Jesus SUPREMA, Fac Ciencia Med & Saude Juiz de Fora, Juiz De Fora, Brazil

[8] Denver Hlth, Ernest E Moore Shock Trauma Ctr, Denver, CO USA

[9] Univ Glasgow, Royal Alexandra Hosp, Paisley & Golden Jubilee Natl Hosp, Dept Surg, Glasgow, Lanark, Scotland

[10] Univ Hosp Pavia, Dept Gen Surg, Pavia, Italy

[11] Rambam Acad Hosp, Dept Gen Surg, Haifa, Israel

[12] Univ Hosp Pisa, Dept Gen & Emergency Surg, Pisa, Italy

[13] Alfredo Espinosa Urduliz Hosp, Urduliz, Spain

[14] Santo Stefano Hosp, Gen Surg Unit, ASL Toscana Ctr, Prato, Italy

[15] Univ Sucre, Clin Santa Maria, Sincelejo, Colombia

[16] John Radcliffe Hosp, Emergency Surg Dept, Oxford, England

[17] Univ Sains Malaysia, Sch Med Sci & Hosp USM, Dept Surg, Kubang Kerian, Kelantan, Malaysia

[18] Hosp San Paolo, UOC Gen & Minimally Invas Surg, Largo Donatori Sangue 1, I-00053 Rome, Italy

[19] AOU Careggi, SOD Chirurg Apparat Digerente, Florence, Italy

[20] Univ Catania, Policlin G Rodolico San Marco Hosp, Dept Surg, Catania, Italy

[21] Carlo Urbani Hosp, UOC Gen Surg, Jesi, AN, Italy

[22] Hosp Ist Citta Pavia, Pavia, Italy

[23] Hosp Sultan Ismail Petra, Dept Gen Surg, Kuala Krai 18000, Kelantan, Malaysia

[24] San Polo Monfalcone, Chirurg Gen & Mininvas, Monfalcone, GO, Italy

[25] Hosp Univ Principe Asturias, Alcala De Henares, Spain

[26] Med Univ Plovdiv, UMHAT Eurohosp, RIMU, Plovdiv, Bulgaria

[27] Osped San Giovanni Decollato Andosilla ASL, Civita Castellana, Viterbo, VT, Italy

[28] Osped Madonna del Soccorso, UOC Chirurg Gen, San Benedetto Tronto, Italy

[29] Lviv Reg Clin Hosp, Lvov, Ukraine

[30] Lorenzo Bonomo Hosp, ASL BAT, Andria, Puglia, Italy

[31] Univ Magna Graecia Med Sch, Mater Domini Hosp, Sci Hlth Dept, Gen Surg Unit, Viale Europa, I-88100 Catanzaro, Italy

[32] Hosp Virgen del Rocio, Emergency Surg Unit, Seville, Spain

[33] Univ Clin Ctr Tuzla, Clin Surg, Tuzla, Bosnia & Herceg

[34] Santa Croce & Carle Hosp, Cuneo, Italy

[35] AOU Citta Salute & Sci, Chirurg Gen Urgenza & PS, Turin, Italy

[36] ASMN IRCCS REGGIO EMILIA, Gen & Emergency Surg, Reggio Emilia, Italy

[37] Univ Padua, Reg Hosp Treviso, DISCOG, Surg Unit 2, Treviso, Italy

[38] Osped San Valentino, UO Chirurg Gen & Urgenza, Treviso, Italy

[39] AUSL Piacenza, Dept Surg, G Da Saliceto Hosp, Piacenza, Italy

[40] Tzaneio Gen Hosp, Dept Surg 3, Styliani Aikaterini Vederaki, Piraeus, Greece

[41] Private Ortadogu Hosp, Clin Surg, Adana, Turkey

[42] Private Medline Hosp, Clin Radiol, Adana, Turkey

[43] Kestel State Hosp, Dept Gen Surg, Bursa, Turkey

[44] Univ Hlth Sci, Bagcilar Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey

[45] Koc Univ, Fac Med, Gen Surg Dept, Istanbul, Turkey

[46] Kavala Gen Hosp, Dept Surg 1, Kavala, Greece

[47] Azienda Osped Univ Ferrara, Dipartimento Chirurg, Arcispedale St Anna, UO Chirurg 1, Ferrara, Italy

[48] Sakarya Training & Res Hosp, Sakarya, Turkey

[49] Lavagna Hosp, Dept Gen Surg ASL 4, Genoa, Italy

[50] Univ Samsun, Samsun Training & Res Hosp, Samsun, Turkey

来源：

WORLD JOURNAL OF EMERGENCY SURGERY | 2022年 / 17卷 / 01期

关键词：

Acute cholecystitis; Cholecystectomy; Gangrene; COVID-19; SARS-CoV-2; Laparoscopy; Surgery; Pandemic; Gangrenous cholecystitis; CHOLECYSTECTOMY; GUIDELINES; MORTALITY;

D O I：

10.1186/s13017-022-00466-4

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

BackgroundThe incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not.MethodsData were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not.ResultsA total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p=0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001].ConclusionsThe incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.

引用

页数：16

共 50 条

[1] The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?
Belinda De Simone
Fikri M. Abu-Zidan
Elie Chouillard
Salomone Di Saverio
Massimo Sartelli
Mauro Podda
Carlos Augusto Gomes
Ernest E. Moore
Susan J. Moug
Luca Ansaloni
Yoram Kluger
Federico Coccolini
Aitor Landaluce-Olavarria
Begoña Estraviz-Mateos
Ana Uriguen-Etxeberria
Alessio Giordano
Alfonso Palmieri Luna
Luz Adriana Hernández Amín
Adriana María Palmieri Hernández
Amanda Shabana
Zakaria Andee Dzulkarnaen
Muhammad Asyraf Othman
Mohamad Ikhwan Sani
Andrea Balla
Rosa Scaramuzzo
Pasquale Lepiane
Andrea Bottari
Fabio Staderini
Fabio Cianchi
Andrea Cavallaro
Antonio Zanghì
Alessandro Cappellani
Roberto Campagnacci
Angela Maurizi
Mario Martinotti
Annamaria Ruggieri
Asri Che Jusoh
Karim Abdul Rahman
Anis Suraya M. Zulkifli
Barbara Petronio
Belén Matías-García
Ana Quiroga-Valcárcel
Fernando Mendoza-Moreno
Boyko Atanasov
Fabio Cesare Campanile
Ilaria Vecchioni
Luca Cardinali
Grazia Travaglini
Elisa Sebastiani
Serge Chooklin
World Journal of Emergency Surgery, 17
[2] COVID-19 infection is a significant risk factor for death in patients presenting with acute cholecystitis: a secondary analysis of the ChoCO-W cohort study
De Simone, Belinda
Abu-Zidan, Fikri M.
Kasongo, Lucienne
Moore, Ernest E.
Podda, Mauro
Sartelli, Massimo
Isik, Arda
Bala, Miklosh
Coimbra, Raul
Balogh, Zsolt J.
Rasa, Kemal
Marchegiani, Francesco
Schena, Carlo Alberto
Deangelis, Nicola
Di Martino, Marcello
Ansaloni, Luca
Coccolini, Federico
Gumbs, Andrew A.
Biffl, Walter L.
Pikoulis, Emmanouil
Pararas, Nikolaos
Chouillard, Elie
ChoCO Collaborative Grp, Salomone
Catena, Fausto
WORLD JOURNAL OF EMERGENCY SURGERY, 2025, 20 (01):
[3] Gangrenous Cholecystitis as a Potential Complication of COVID-19: A Case Report
Alam, Walid
Karam, Karam
CLINICAL MEDICINE INSIGHTS-CASE REPORTS, 2021, 14
[4] Risk factors for necrotic cholecystitis during the COVID-19 pandemic: the ChoCO-WSES prospective collaborative study's experience
de Simone, Belinda
Catena, Fausto
Di Saverio, Salomone
Sartelli, Massimo
Abu-Zidan, Fikri M.
Podda, Mauro
Biffl, Walter L.
Ansaloni, Luca
Coccolini, Federico
Moore, Ernest E.
Kluger, Yoram
Gomes, Carlos Augusto
Agresta, Ferdinando
Chouillard, Elie
TURKISH JOURNAL OF SURGERY, 2021, 37 (04) : 387 - 393
[5] Histopathological findings in a COVID-19 patient affected by ischemic gangrenous cholecystitis
Andrea Bruni
Eugenio Garofalo
Valeria Zuccalà
Giuseppe Currò
Carlo Torti
Giuseppe Navarra
Giovambattista De Sarro
Paolo Navalesi
Federico Longhini
Michele Ammendola
World Journal of Emergency Surgery, 15
[6] Histopathological findings in a COVID-19 patient affected by ischemic gangrenous cholecystitis
Bruni, Andrea
Garofalo, Eugenio
Zuccala, Valeria
Curro, Giuseppe
Torti, Carlo
Navarra, Giuseppe
De Sarro, Giovambattista
Navalesi, Paolo
Longhini, Federico
Ammendola, Michele
WORLD JOURNAL OF EMERGENCY SURGERY, 2020, 15 (01)
[7] COVID-19 patients presenting with gangrenous acalculous cholecystitis: Report of two cases
Hajebi, Reza
Habibi, Pedram
Maroufi, Seyed Farzad
Bahreini, Maryam
Yazdi, Seyed Amir Miratashi
ANNALS OF MEDICINE AND SURGERY, 2022, 76
[8] Laparoscopic cholecystectomy for acalculous, gangrenous cholecystitis on an outpatient COVID-19 adult: a case report
Liapis, Stavros Chrysovalantis
Stavrou, Alexios
Perivoliotis, Konstantinos
Christodoulou, Prokopis
Kalodimos, Georgios
Kitsakis, Georgios
Kapatou, Kassiani
Ziamas, Dimitrios
Lytras, Dimitrios
JOURNAL OF SURGICAL CASE REPORTS, 2022, 2022 (05):
[9] Benefits of pulmonary rehabilitation in COVID-19: a prospective observational cohort study
Gloeckl, Rainer
Leitl, Daniela
Jarosch, Inga
Schneeberger, Tessa
Nell, Christoph
Stenzel, Nikola
Vogelmeier, Claus F.
Kenn, Klaus
Koczulla, Andreas R.
ERJ OPEN RESEARCH, 2021, 7 (02)
[10] Antibody kinetics and clinical course of COVID-19 a prospective observational study
Blackberg, Anna
Fernstrom, Nils
Sarbrant, Emma
Rasmussen, Magnus
Sunnerhagen, Torgny
PLOS ONE, 2021, 16 (03):

← 1 2 3 4 5 →