Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children

被引：3
|
作者：
Brown, Elizabeth E.
Brown, Brandon J.
Yeager, Meredith
Welch, Robert
Cranston, Beverly
Hanchard, Barrie
Hisada, Michie
机构：
[1] NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA
[2] NCI, Sci Applicat Int Corp Frederick Inc, Core Genotyping Facil, Ctr Adv Technol, Gaithersburg, MD USA
[3] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA
[4] Univ W Indies, Dept Pathol, Kingston 7, Jamaica
来源：
JOURNAL OF INFECTIOUS DISEASES | 2006年 / 194卷 / 11期
关键词：
D O I：
10.1086/508783
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To characterize a host polygenic profile associated with susceptibility to human T lymphotropic virus type I (HTLV-I) infection, we examined common variants in 11 immunerelated genes among Jamaican children born to HTLV-I seropositive mothers. Compared with HTLV-I seronegatives, haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding (odds ratio [OR], 4.5 [95% confidence interval {CI}, 1.2-17.6], and OR, 3.5 [95% CI, 1.4-9.0], respectively). Our findings are the first, to our knowledge, to suggest that host variation in both proinflammatory and anti-inflammatory genes could influence susceptibility to HTLV-I infection.
引用
收藏
页码：1565 / 1569
页数：5
相关论文
共 50 条
  • [41] Effect of IL4 and IL10 on a human in vitro type 1 diabetes model
    Von Herrath, Matthias
    Pfeiffer, Susanne E. M.
    Quesada-Masachs, Estefania
    McArdle, Sara
    Zilberman, Samuel
    Yesildag, Burcak
    Mikulski, Zbigniew
    CLINICAL IMMUNOLOGY, 2022, 241
  • [42] Evaluation of IL6, IL10 and VDR alleles distribution in an Italian large sample of subjects affected by chronic periodontal disease
    Scapoli, Luca
    Carinci, Francesco
    Mucchi, Damiano
    Nota, Alessandro
    Caruso, Silvia
    Rossi, Diego
    Romano, Michele
    Severino, Marco
    INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2019, 33
  • [43] TNF-α, IL6, and IL10 polymorphisms and the effect of physical exercise on inflammatory parameters and physical performance in elderly women
    Daniele Sirineu Pereira
    Elvis Cristian Cueva Mateo
    Bárbara Zille de Queiroz
    Alexandra Miranda Assumpção
    Aline Silva Miranda
    Diogo Carvalho Felício
    Natália Pessoa Rocha
    Daniela Maria da Cruz dos Anjos
    Danielle Aparecida Gomes Pereira
    Antonio Lucio Teixeira
    Leani Souza Máximo Pereira
    AGE, 2013, 35 : 2455 - 2463
  • [44] Interplay of interleukins (IL6, IL10) and 25 hydroxycholecalciferol in asthmatic subjects with chronic post-COVID condition (PCC)
    Jaleel, A.
    Namoos, K.
    Asim, S.
    Uppal, S. S.
    Zaman, S.
    Irfan, H.
    Pervaiz, S.
    Tariq, M.
    Shafique, M.
    TROPICAL BIOMEDICINE, 2024, 41 (01) : 70 - 77
  • [45] Detection of a major gene predisposing to human T lymphotropic virus type I infection in children among an endemic population of African origin
    Plancoulaine, S
    Gessain, A
    Joubert, M
    Tortevoye, P
    Jeanne, I
    Talarmin, A
    de Thé, G
    Abel, L
    JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (02): : 405 - 412
  • [46] Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and Childhood-Onset Mood Disorders
    Misener, V. L.
    Gomez, L.
    Wigg, K. G.
    Luca, P.
    King, N.
    Kiss, E.
    Daroczi, G.
    Kapornai, K.
    Tamas, Z.
    Mayer, L.
    Gadoros, J.
    Baji, I.
    Kennedy, J. L.
    Kovacs, M.
    Vetro, A.
    Barr, C. L.
    NEUROPSYCHOBIOLOGY, 2008, 58 (02) : 71 - 80
  • [47] INVESTIGATION OF IL1B, IL1RN, IL4, IL6 AND IL10 GENE POLYMORPHISM IN ADULT PATIENTS WITH IMMUNE THROMBOCYTOPENIC PURPURA
    Vilela, J.
    De Paula, E.
    Annichino-Bizzacchi, J.
    Addas-Carvalho, M.
    HAEMATOLOGICA, 2012, 97 : 429 - 430
  • [48] Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses
    de Sa, A. R.
    Moreira, P. R.
    Xavier, G. M.
    Sampaio, I.
    Kalapothakis, E.
    Dutra, W. O.
    Gomez, R. S.
    INTERNATIONAL ENDODONTIC JOURNAL, 2007, 40 (07) : 563 - 572
  • [49] HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN T-LYMPHOTROPIC VIRUS TYPE-I INFECTION AMONG HOMOSEXUAL MEN IN KINGSTON, JAMAICA
    MURPHY, EL
    GIBBS, WN
    FIGUEROA, JP
    BAIN, B
    LAGRENADE, L
    CRANSTON, B
    BLATTNER, WA
    JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1988, 1 (02): : 143 - 149
  • [50] Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection
    Stahelova, Anna
    Mrazek, Frantisek
    Smizansky, Matej
    Petrek, Martin
    Gallo, Jiri
    BMC IMMUNOLOGY, 2012, 13
12345