Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children

被引：3

作者：

Brown, Elizabeth E.

Brown, Brandon J.

Yeager, Meredith

Welch, Robert

Cranston, Beverly

Hanchard, Barrie

Hisada, Michie

机构：

[1] NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA

[2] NCI, Sci Applicat Int Corp Frederick Inc, Core Genotyping Facil, Ctr Adv Technol, Gaithersburg, MD USA

[3] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA

[4] Univ W Indies, Dept Pathol, Kingston 7, Jamaica

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 194卷 / 11期

关键词：

D O I：

10.1086/508783

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To characterize a host polygenic profile associated with susceptibility to human T lymphotropic virus type I (HTLV-I) infection, we examined common variants in 11 immunerelated genes among Jamaican children born to HTLV-I seropositive mothers. Compared with HTLV-I seronegatives, haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding (odds ratio [OR], 4.5 [95% confidence interval {CI}, 1.2-17.6], and OR, 3.5 [95% CI, 1.4-9.0], respectively). Our findings are the first, to our knowledge, to suggest that host variation in both proinflammatory and anti-inflammatory genes could influence susceptibility to HTLV-I infection.

引用

页码：1565 / 1569

页数：5

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