Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer

被引：6
|
作者：
Banno, Kouji [1 ]
Yanokura, Megumi [1 ]
Susumu, Nobuyuki [1 ]
Kawaguchi, Makiko [1 ]
Hirao, Nobumaru [1 ]
Hirasawa, Akira [1 ]
Tsukazaki, Katsumi [1 ]
Aoki, Daisuke [1 ]
机构：
[1] Keio Univ, Sch Med, Dept Obstet & Gynecol, Shinjuku Ku, Tokyo 1608582, Japan
来源：
ONCOLOGY REPORTS | 2006年 / 16卷 / 06期
关键词：
endometrial cancer; DNA hypermethylation; human MutL homolog-1; E-cadherin; adenomatous polyposis coli; retinoic acid receptor-beta;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epigenetic abnormalities including the aberrant DNA hypermethylation of the promoter CpG islands play a key role in the mechanism of gene inactivation in cell carcinogenesis. To identify the genes associated with aberrant DNA hypermethylation in endometrial carcinogenesis, we studied the. hypermethylation of the promoter regions of five genes: hMLH1, APC, E-cadherin, RAR-beta and p16. The frequencies of aberrant hypermethylation were 40.4% (21/52) in hMLH1, 22% (11/50) in APC, 14% (7/50) in E-cadherin, and 2.3% (1/44) in RAR-beta in endometrial cancer specimens. No aberrant DNA methylation was found in p16. In atypical endometrial hyperplasia, the frequencies of aberrant methylation were 14.3% (2/14) in hMLH1 and 7.3% (1/14) in APC, whereas normal endometrial cells showed no aberrant hypermethylation of any of the five genes. The high frequencies of the aberrant DNA hypermethylation of hMLH1, APC and E-cadherin suggest that the methylation of the DNA mismatch repair and Wnt signal-related genes may be associated with endometrial carcinogenesis.
引用
收藏
页码：1189 / 1196
页数：8
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