The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose

被引：67
|
作者：
Edge, S
Steele, DF
Chen, AS
Tobyn, MJ
Staniforth, JN [1 ]
机构：
[1] Univ Bath, Dept Pharm & Pharmacol, Pharmaceut Technol Res Grp, Bath BA2 7AY, Avon, England
[2] Univ Bath, Dept Mat Sci & Engn, Bath BA2 7AY, Avon, England
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 200卷 / 01期
关键词：
silicified microcrystalline cellulose; mechanical property; strength;
D O I：
10.1016/S0378-5173(00)00343-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited greater strength than those of microcrystalline cellulose. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater stiffness and required considerably more energy for tensile failure to occur. Comparison of the data with that obtained for a dry blend of silicon dioxide/microcrystalline cellulose suggested that the functionality benefits of silicification were not due to a simple composite material model. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：67 / 72
页数：6
相关论文
共 50 条
  • [31] MICROCRYSTALLINE CELLULOSE FOR COSMETICS
    STEVENS, EP
    STEVERNAGEL, CR
    [J]. DRUG & COSMETIC INDUSTRY, 1978, 122 (06): : 54 - &
  • [32] DRUG ADDUCTS WITH MICROCRYSTALLINE CHITOSAN AND MICROCRYSTALLINE CELLULOSE
    ZIEBA, J
    KNAPCZYK, J
    [J]. ACTA PHARMACEUTICA TECHNOLOGICA-INTERNATIONAL JOURNAL OF DRUG FORUMLATION AND BIOPHARMACEUTICS, 1988, 34 (02): : 84 - 87
  • [33] PERSORPTION OF MICROCRYSTALLINE CELLULOSE
    PAHLKE, G
    FRIEDRICH, R
    [J]. NATURWISSENSCHAFTEN, 1974, 61 (01) : 35 - 35
  • [34] Weight and weight uniformity of hard gelatin capsules filled with micro crystalline cellulose and silicified microcrystalline cellulose
    Felton, LA
    Garcia, DI
    Farmer, R
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2002, 28 (04) : 467 - 472
  • [35] MICROCRYSTALLINE COLLOIDAL CELLULOSE
    BATTISTA, OA
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1974, : 29 - 29
  • [36] MICROCRYSTALLINE CELLULOSE IN TABLETING
    REIER, GE
    SHANGRAW, RF
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1966, 55 (05) : 510 - &
  • [37] EIFECT OF SIMULTANEOUSLY SILICIFIED MICROCRYSTALLINE CELLULOSE AND PREGELATINIZED STARCH ON THE THEOPHYLLINE TABLETS STABILITY
    Mazurek-Wadolkowska, Edyta
    Winnicka, Katarzyna
    Czyzewska, Urszula
    Miltyk, Wojciech
    [J]. ACTA POLONIAE PHARMACEUTICA, 2016, 73 (04): : 1029 - 1036
  • [38] AVAILABILITY STUDY OF MICROCRYSTALLINE CELLULOSE IN MAKING PHENOBARBITALE-TABLETS .3. INFLUENCE OF MICROCRYSTALLINE CELLULOSE, MICROCRYSTALLINE CELLULOSE AND LACTOSE, MICROCRYSTALLINE CELLULOSE AND CORN-STARCH ON THE PARAMETERS OF THE TABLETS
    PINTYEHODI, K
    SZABOREVESZ, P
    [J]. PHARMAZEUTISCHE INDUSTRIE, 1986, 48 (09): : 1079 - 1082
  • [39] Effect of post-compaction heating on characteristics of microcrystalline cellulose compacts
    Gharaibeh, Shadi F.
    Obeidat, Wasfy M.
    Al-Zoubi, Nizar
    [J]. E-POLYMERS, 2022, 22 (01) : 536 - 543
  • [40] Study of Thermal and. Mechanical Properties of Microcrystalline Cellulose and Nanocrystalline Cellulose Based Thermoplastic Material
    Samarasekara, A. M. P. B.
    Kumara, S. P. D. A.
    Madhusanka, A. J. S.
    Amarasinghe, D. A. S.
    Karunanayake, L.
    [J]. 2018 MORATUWA ENGINEERING RESEARCH CONFERENCE (MERCON) 4TH INTERNATIONAL MULTIDISCIPLINARY ENGINEERING RESEARCH CONFERENCE, 2018, : 465 - 470
12345