Involvement of cyclin D1 in estrogen-induced cell growth of normal endometrium and endometrial carcinoma cells

被引：0
|
作者：
Shiozawa, T [1 ]
Shih, HC [1 ]
Miyamoto, T [1 ]
Nikaido, T [1 ]
Konishi, I [1 ]
机构：
[1] Shinshu Univ, Sch Med, Dept Obstet & Gynecol, Matsumoto, Nagano, Japan
来源：
9TH BIENNIAL MEETING OF THE INTERNATIONL GYNECOLOGIC CANCER SOCIETY | 2002年
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The involvement of cell cycle-regulators in steroid hormone-dependent growth was examined using cultured normal endometrial glandular cells and ER-positive endometrial carcinoma (Ishikawa) cells. The results indicated that the E2-induced up-regulation of cyclin D1 may play a crucial role in the growth of normal endometrial glandular cells, and is mediated by c-Jun via AP-1-binding site-like sequence of the promoter. In Ishikawa cells, however, its molecular mechanism is different from the normal counterpart.
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页码：217 / 220
页数：4
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