Involvement of cyclin D1 in estrogen-induced cell growth of normal endometrium and endometrial carcinoma cells

被引：0

作者：

Shiozawa, T ^{[1
]}

Shih, HC ^{[1
]}

Miyamoto, T ^{[1
]}

Nikaido, T ^{[1
]}

Konishi, I ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Obstet & Gynecol, Matsumoto, Nagano, Japan

来源：

9TH BIENNIAL MEETING OF THE INTERNATIONL GYNECOLOGIC CANCER SOCIETY | 2002年

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D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The involvement of cell cycle-regulators in steroid hormone-dependent growth was examined using cultured normal endometrial glandular cells and ER-positive endometrial carcinoma (Ishikawa) cells. The results indicated that the E2-induced up-regulation of cyclin D1 may play a crucial role in the growth of normal endometrial glandular cells, and is mediated by c-Jun via AP-1-binding site-like sequence of the promoter. In Ishikawa cells, however, its molecular mechanism is different from the normal counterpart.

引用

页码：217 / 220

页数：4

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