Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes

被引：9
|
作者：
McEvoy, Christopher R. E. [1 ]
Warren, Robin M. [1 ]
van Helden, Paul D. [1 ]
Gey van Pittius, Nicolaas C. [1 ]
机构：
[1] Univ Stellenbosch, DST NRF Ctr Excellence Biomed TB Research, MRC Ctr Mol & Cellular Biol, Div Mol Biol & Human Genet,Fac Hlth Sci, ZA-7505 Tygerberg, South Africa
来源：
TUBERCULOSIS | 2009年 / 89卷 / 06期
关键词：
IS6110; PPE; Transposable elements; IS6110 insertion sequence; PPE family; NONRANDOM ASSOCIATION; CLONAL EXPANSION;
D O I：
10.1016/j.tube.2009.08.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IS6110 is a transposable element found in Mycobacterium tuberculosis complex members. Regions of preferential IS6110 integration occur within the M. tuberculosis genome but the element has not previously been shown to exhibit any sequence-specific integration preferences. Here we provide evidence for multiple independent IS6110 insertions into identical, or near-identical, positions within the highly homologous 50 region of 3 PPE genes. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：439 / 442
页数：4
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