The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock

被引：2
|
作者：
Zhao, Jing [1 ,4 ]
Yan, Chengbin [1 ]
Xu, Lijuan [1 ]
Yan, Kunping [1 ]
Feng, Bao [3 ]
Zhao, Mengye [1 ]
Niu, Geng [1 ]
Wu, Mengdi [1 ]
Chen, Chao [1 ,2 ]
Zhu, Hongli [1 ,2 ]
机构：
[1] Northwest Univ Xian, Coll Life Sci, Xian 710069, Peoples R China
[2] Northwest Univ Xian, Natl Engn Res Ctr Miniaturized Detect Syst, Xian 710069, Peoples R China
[3] Shaanxi Lifegen Co Ltd, Xian, Peoples R China
[4] Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol, Xian, Peoples R China
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Polymerized porcine hemoglobin; hemorrhagic shock; hemodynamic stability; mesenteric microcirculation; POLYMERIZED PORCINE HEMOGLOBIN; OXYGEN CARRIER HBOC-201; HUMAN PLACENTA HEMOGLOBIN; BOVINE HEMOGLOBIN; VOLUME RESUSCITATION; LIVER-INJURY; SWINE MODEL; VASOCONSTRICTION; ACIDOSIS; EFFICACY;
D O I：
10.1080/21691401.2017.1282869
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and maintenance of mesenteric microvascular function were explored in a rat model of hemorrhagic shock (HS). Following controlled hemorrhage, rats were infused with equal volumes of either pPolyHb, hetastarch (HES), or red blood cell (RBC). The results showed that pPolyHb was superior to HES and RBC in restoring hemodynamic stability and reversing anaerobic metabolism. We observed a reduction in the diameter of mesenteric microvasculature after HS. Resuscitation with pPolyHb and RBC was able to restore the diameters of the venules and arterioles, whereas HES failed to restore the diameters during the observation period.
引用
收藏
页码：677 / 685
页数：9
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