Implementation of Diverse Synthetic and Strategic Approaches to Biologically Active Sulfamides

被引：15

作者：

Jun, Jaden J. ^{[1
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Xie, Xiang-Qun ^{[1
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机构：

[1] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, 335 Sutherland Dr,206 Salk Pavil, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Sch Pharm, Computat Chem Genom Screening Ctr, 335 Sutherland Dr,206 Salk Pavil, Pittsburgh, PA 15261 USA

[3] NIH, Natl Ctr Excellence Computat Drug Abuse Res, Pittsburgh, PA 15261 USA

[4] Drug Discovery Inst, Pittsburgh, PA 15261 USA

[5] Univ Pittsburgh, Sch Med, Dept Computat Biol, Pittsburgh, PA 15261 USA

[6] Univ Pittsburgh, Sch Med, Dept Struct Biol, Pittsburgh, PA 15261 USA

[7] Univ Pittsburgh, Sch Med, CCGS Ctr, Pittsburgh, PA 15261 USA

[8] Univ Pittsburgh, Sch Med, NIDA CDAR Ctr, Pittsburgh, PA 15261 USA

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 03期

关键词：

Asymmetric synthesis; catalyst; chiral auxiliaries; ring-closing metathesis (RCM); small molecule synthesis; small ring systems; sulfamide; RING-CLOSING METATHESIS; ASYMMETRIC ALDOL REACTIONS; HIV-1 PROTEASE INHIBITORS; POLYSTYRENE SUPPORTED CYCLOSULFAMIDE; MATRIX-METALLOPROTEINASE INHIBITORS; CARBONIC-ANHYDRASE INHIBITORS; SMALL-MOLECULE INHIBITORS; OXIDE PRODUCING REACTIONS; STATE ANALOG INHIBITORS; STRUCTURE-BASED DESIGN;

D O I：

10.1002/slct.202004765

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sulfamide compounds are an important class of motif in various applications in pharmaceutical agents, agriculture, and material science. In this review, various synthetic strategies toward acyclic and cyclic sulfamide compounds utilizing many different methods are described. Herein, efficient and innovative synthetic methods ranging from small molecules to large rings for bioactive compounds, small molecules, and catalyst development are discussed.

引用

页码：430 / 469

页数：40

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