Synthetic approaches to biologically active bisphosphonates and phosphonocarboxylates

被引：0
|
作者：
McKenna, CE [1 ]
Kashemirov, BA [1 ]
Li, ZM [1 ]
机构：
[1] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1999年 / 144卷
关键词：
anti-resorptive; cancer; anti-viral; AIDS; foscarnet; thiophosphonoformate; carbonylbisphosphonate; etidronate;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Some current and potential therapeutic uses of bisphosphonates and phosphonocarboxylates are summarized. The feasibility of synthesizing alpha-hydroxy alpha-alkyl/aryl methyl-enebisphosphonates via Grignard addition to tetraalkyl carbonylbisphosphonates 6 is demonstrated, and a new synthesis of 6 under very mild conditions is described.
引用
收藏
页码：313 / 316
页数：4
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