Effects of Sample Handling and Analytical Procedures on Thyroid Hormone Concentrations in Pregnant Women's Plasma

被引：9
|
作者：
Villanger, Gro Dehli [1 ]
Learner, Emily [2 ]
Longnecker, Matthew P. [3 ]
Ask, Helga [1 ]
Aase, Heidi [1 ]
Zoeller, R. Thomas [4 ]
Knudsen, Gun P. [1 ]
Reichborn-Kjennerud, Ted [1 ]
Zeiner, Pal [5 ]
Engel, Stephanie M. [2 ]
机构：
[1] Norwegian Inst Publ Hlth, Mental & Phys Hlth, Oslo, Norway
[2] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA
[3] NIEHS, NIH, Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA
[4] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA
[5] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
来源：
EPIDEMIOLOGY | 2017年 / 28卷 / 03期
基金：
美国国家卫生研究院;
关键词：
LONG-TERM STORAGE; MATERNAL HYPOTHYROXINEMIA; NORWEGIAN MOTHER; CHILD COHORT; WHOLE-BLOOD; SERUM; STABILITY; ASSOCIATION; THYROTROPIN; DISORDER;
D O I：
10.1097/EDE.0000000000000606
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background: Maternal thyroid function is a critical mediator of fetal brain development. Pregnancy-related physiologic changes and handling conditions of blood samples may influence thyroid hormone biomarkers. We investigated the reliability of thyroid hormone biomarkers in plasma of pregnant women under various handling conditions. Methods: We enrolled 17 pregnant women; collected serum and plasma were immediately frozen. Additional plasma aliquots were subjected to different handling conditions before the analysis of thyroid biomarkers: storage at room temperature for 24 or 48 hours before freezing and an extra freeze-thaw cycle. We estimated free thyroid hormone indices in plasma based on T3 uptake. Results: High correlations between plasma and serum (> 0.94) and intraclass correlation coefficients for plasma handling conditions (0.96 to 1.00) indicated excellent reliability for all thyroid hormone biomarkers. Conclusion: Delayed freezing and freeze-thaw cycles did not affect reliability of biomarkers of thyroid function in plasma during pregnancy.
引用
收藏
页码：365 / 369
页数：5
相关论文
共 50 条
  • [31] Serum Dioxin Concentrations and Thyroid Hormone Levels in the Seveso Women's Health Study
    Chevrier, Jonathan
    Warner, Marcella
    Gunier, Robert B.
    Brambilla, Paolo
    Eskenazi, Brenda
    Mocarelli, Paolo
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 2014, 180 (05) : 490 - 498
  • [32] EFFECTS OF ALCOHOL-CONSUMPTION ON PLASMA AND URINARY HORMONE CONCENTRATIONS IN PREMENOPAUSAL WOMEN
    REICHMAN, ME
    JUDD, JT
    LONGCOPE, C
    SCHATZKIN, A
    CLEVIDENCE, BA
    NAIR, PP
    CAMPBELL, WS
    TAYLOR, PR
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (09) : 722 - 727
  • [33] Assessment of Joint Impact of Iodine, Selenium, and Zinc Status on Women's Third-Trimester Plasma Thyroid Hormone Concentrations
    Gustin, Klara
    Vahter, Marie
    Barman, Malin
    Jacobsson, Bo
    Skroder, Helena
    Filipsson Nystrom, Helena
    Sandin, Anna
    Sandberg, Ann-Sofie
    Wold, Agnes E.
    Kippler, Maria
    JOURNAL OF NUTRITION, 2022, 152 (07): : 1737 - 1746
  • [34] TEMPORAL EFFECTS OF PITUITARY-HORMONE PREPARATIONS ON PLASMA THYROID-HORMONE CONCENTRATIONS IN RAINBOW-TROUT
    MILNE, RS
    LEATHERLAND, JF
    JOURNAL OF ENDOCRINOLOGY, 1980, 85 (02) : P37 - P38
  • [35] Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women
    Nien, Jyh Kae
    Mazaki-Tovi, Shali
    Romero, Roberto
    Erez, Offer
    Kusanovic, Juan Pedro
    Gotsch, Francesca
    Pineles, Beth L.
    Gomez, Ricardo
    Edwin, Samuel
    Mazor, Moshe
    Espinoza, Jimmy
    Yoon, Bo Hyun
    Hassan, Sonia S.
    JOURNAL OF PERINATAL MEDICINE, 2007, 35 (06) : 522 - 531
  • [36] Comparison of various sample handling and analytical procedures for the monitoring of pesticides and metabolites in ground waters
    J Chromatogr, 1-2 (35-47):
  • [37] Comparison of various sample handling and analytical procedures for the monitoring of pesticides and metabolites in ground waters
    Fernandez-Alba, AR
    Agüera, A
    Contreras, M
    Peñuela, G
    Ferrer, I
    Barceló, D
    JOURNAL OF CHROMATOGRAPHY A, 1998, 823 (1-2) : 35 - 47
  • [38] Effect of thyroid hormone on concentrations of plasma calcitonin in broiler chicks
    Klandorf, H
    Boyce, CS
    Holt, SB
    Iqbal, M
    Killefer, J
    Peterson, RA
    Deaver, DR
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1999, 122 (01): : 55 - 60
  • [39] Fetal Free Thyroxine Concentrations in Pregnant Women with Autoimmune Thyroid Disease
    Spremovic-Radjenovic, Svetlana
    Gudovic, Aleksandra
    Lazovic, Gordana
    Marinkovic, Jelena
    Radunovic, Nebojsa
    Ljubic, Aleksandar
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (11): : 4014 - 4021
  • [40] THE EFFECTS OF PLASMAPHERESIS ON THYROID-HORMONE AND PLASMA DRUG CONCENTRATIONS IN AMIODARONE-INDUCED THYROTOXICOSIS
    UZZAN, B
    PUSSARD, E
    LEON, A
    BEKHECHI, D
    KRIVITZKY, A
    MODIGLIANI, E
    PERRET, G
    VASSY, R
    BERDEAUX, A
    GIUDICELLI, JF
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1991, 31 (03) : 371 - 372
12345