The innovative development in interferon beta treatments of relapsing-remitting multiple sclerosis

被引：41
|
作者：
Madsen, Claus [1 ]
机构：
[1] Odense Univ Hosp, Dept Neurol, Odense C, Denmark
来源：
BRAIN AND BEHAVIOR | 2017年 / 7卷 / 06期
关键词：
interferon beta; multiple sclerosis; peginterferon beta-1a; RRMS; DISEASE-MODIFYING THERAPIES; NEUTRALIZING ANTIBODIES; PEGINTERFERON BETA-1A; ADHERENCE; NEOPTERIN; IMPACT; PHARMACOLOGY; PREGNANCY; OUTCOMES; MARKER;
D O I：
10.1002/brb3.696
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The introduction of interferon beta therapies more than 20 years ago marked a milestone in the treatment of relapsing-remitting multiple sclerosis (RRMS) with a significant impact on the approach to modern multiple sclerosis (MS) care. Key learnings and perspectives from the early days of disease modifying therapies in MS have improved the knowledge base of MS, need for treatment, and patient care. The continuous development of interferons over the past two decades outlines a journey with increased understanding of the pharmacodynamics and pharmacokinetic mechanisms of interferons, leading to innovative formulations with an improved benefit/risk profile.
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页数：8
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