Triterpenoids from the leaves of Psidium guajava']java

被引：76
|
作者：
Begum, S [1 ]
Hassan, SI
Siddiqui, BS
Shaheen, F
Ghayur, MN
Gilani, AH
机构：
[1] Univ Karachi, HEJ Res Inst Chem, Karachi 75270, Pakistan
[2] Aga Khan Univ, Coll Med, Dept Biol & Biomed Sci, Karachi 74800, Pakistan
来源：
PHYTOCHEMISTRY | 2002年 / 61卷 / 04期
关键词：
Psidium gua[!text type='java']java[!/text; triterpenoids; guavanoic acid; guavacoumaric acid; spasmolytic activity;
D O I：
10.1016/S0031-9422(02)00190-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two triterpenoids, 20beta-acetoxy-2alpha,3beta-dihydroxyurs-12-en-28-oic acid (guavanoic acid, 3), and 2alpha,3beta-dihydroxy-24-p-z-coumaroyloxyurs- 12-en-28-oic acid (guavacoumaric acid, 7), along with six known compounds 2alpha-hydroxyursolic acid (1), jacoumaric acid (2), isoneriucoumaric acid (4), asiatic acid (5), ilelatifol D (6) and beta-sitosterol-3-O-beta-D-glucopyranoside (8), have been isolated from the leaves of Psidium guajava. Their structures were determined through spectroscopic methods. Compound 5 showed dose-dependent (10-500 mug/ml) spasmolytic activity in spontaneously contracting isolated rabbit jejunum preparations. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：399 / 403
页数：5
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