α-Glucosidase inhibitory activities of constituents from Psidium guajava']java leaves

被引：1
|
作者：
Zheng, Muxin [1 ]
Chen, Shenghao [1 ]
Liu, Yi [1 ]
He, Yang [1 ,2 ,3 ]
机构：
[1] Guangdong Pharmaceut Univ, Zhongshan, Peoples R China
[2] Guangdong Cosmet Engn & Technol Res Ctr, Zhongshan, Peoples R China
[3] Macau Univ Sci & Technol, Macau, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 12期
关键词：
Psidium gua[!text type='java']java[!/text; alpha-glucosidase inhibition; guava leaves extract; flavonoids; polyphenol;
D O I：
10.1080/14786419.2023.2238113
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Psidium guajava is a plant of the Myrtaceae with various pharmacological activity. In this study, the water extract and the isolated compounds from guava leaves were evaluated for in vitro a-glucosidase inhibition using spectrophotometric method. Ellagic acid, quercetin, quercetin-3-O-glucuronide, avicularin, isoquercitrin, and quercetin-3-galactoside showed a-glucosidase inhibitory activity, and their IC50 value were 25.0, 41.0, 53.5, 46.9, 60.0 and 72.1 mu g/ mL, respectively compared with the positive control acarbose (IC50 49.2 mu g/mL). This study could provide a theoretical basis for the application of Psidium guajava in the treatment of hyperglycemia. [GRAPHICS.]Y
引用
收藏
页码：2040 / 2043
页数：4
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