Cardiovascular Aging and Longevity JACC State-of-the-Art Review

被引：47
|
作者：
Pietri, Panagiota [1 ,2 ]
Stefanadis, Christodoulos [1 ,2 ]
机构：
[1] Univ Athens, Athens Med Sch, Tepeleniou 9, Athens 15452, Attica, Greece
[2] Res Inst Longev & Aging Related Dis, Athens, Greece
来源：
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2021年 / 77卷 / 02期
关键词：
aging; cardiovascular disease; longevity; NF-KAPPA-B; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; LIFE-SPAN; OXIDATIVE STRESS; ARTERIAL STIFFNESS; ENDOTHELIAL FUNCTION; PHYSICAL-ACTIVITY; TELOMERE LENGTH; PREMATURE SENESCENCE;
D O I：
10.1016/j.jacc.2020.11.023
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dystipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goat of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations. (C) 2021 by the American College of Cardiology Foundation.
引用
收藏
页码：189 / 204
页数：16
相关论文
共 50 条
  • [21] Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review
    Vervoort, Dominique
    Wang, Ruoting
    Li, Guowei
    Filbey, Lynaea
    Maduka, Omosivie
    Brewer, LaPrincess C.
    Mamas, Mamas A.
    Bahit, Maria Cecilia
    Ahmed, Sofia B.
    Van Spall, Harriette G. C.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2024, 83 (25) : 2690 - 2707
  • [22] Screening and Management of Depression in Patients With Cardiovascular Disease JACC State-of-the-Art Review
    Jha, Manish K.
    Qamar, Arman
    Vaduganathan, Muthiah
    Charney, Dennis S.
    Murrough, James W.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (14) : 1827 - 1845
  • [23] Transcatheter Electrosurgery JACC State-of-the-Art Review
    Khan, Jaffar M.
    Rogers, Toby
    Greenbaum, Adam B.
    Babaliaros, Vasilis C.
    Yildirim, Dursun Korel
    Bruce, Christopher G.
    Herzka, Daniel A.
    Schenke, William H.
    Ratnayaka, Kanishka
    Lederman, Robert J.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (12) : 1455 - 1470
  • [24] Orthostatic Hypotension JACC State-of-the-Art Review
    Freeman, Roy
    Abuzinadah, Ahmad R.
    Gibbons, Christopher
    Jones, Pearl
    Miglis, Mitchell G.
    Sinn, Dong In
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 72 (11) : 1294 - 1309
  • [25] Coronary Microvascular Dysfunction Across the Spectrum of Cardiovascular Diseases JACC State-of-the-Art Review
    Del Buono, Marco Giuseppe
    Montone, Rocco A.
    Camilli, Massimiliano
    Carbone, Salvatore
    Narula, Jagat
    Lavie, Carl J.
    Niccoli, Giampaolo
    Crea, Filippo
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 78 (13) : 1352 - 1371
  • [26] Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease JACC State-of-the-Art Review
    Yurista, Salva R.
    Chong, Cher-Rin
    Badimon, Juan J.
    Kelly, Daniel P.
    de Boer, Rudolf A.
    Westenbrink, B. Daan
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 77 (13) : 1660 - 1669
  • [27] Interventions for Frailty Among Older Adults With Cardiovascular Disease JACC State-of-the-Art Review
    Ijaz, Naila
    Buta, Brian
    Xue, Qian-Li
    Mohess, Denise T.
    Bushan, Archana
    Tran, Henry
    Batchelor, Wayne
    DeFilippi, Christopher R.
    Walston, Jeremy D.
    Bandeen-Roche, Karen
    Forman, Daniel E.
    Resar, Jon R.
    O'Connor, Christopher M.
    Gerstenblith, Gary
    Damluji, Abdulla A.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2022, 79 (05) : 482 - 503
  • [28] Consumer Wearable Health and Fitness Technology in Cardiovascular Medicine JACC State-of-the-Art Review
    Petek, Bradley J.
    Al-Alusi, Mostafa A.
    Moulson, Nathaniel
    Grant, Aubrey J.
    Besson, Cyril
    Guseh, J. Sawalla
    Wasfy, Meagan M.
    Gremeaux, Vincent
    Churchill, Timothy W.
    Baggish, Aaron L.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2023, 82 (03) : 245 - 264
  • [29] Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents JACC State-of-the-Art Review
    Rao, Vijay U.
    Reeves, David J.
    Chugh, Atul R.
    O'Quinn, Rupal
    Fradley, Michael G.
    Raghavendra, Meghana
    Dent, Susan
    Barac, Ana
    Lenihan, Daniel
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 77 (21) : 2693 - 2716
  • [30] Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease JACC State-of-the-Art Review
    Narayan, Vivek
    Thompson, Elizabeth W.
    Demissei, Biniyam
    Ho, Jennifer E.
    Januzzi, James L., Jr.
    Ky, Bonnie
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (21) : 2726 - 2737
12345