Hypoxia-inducible factor HIF-1α: pharmacogenetic perspective for bevacizumab therapy individualization

被引：0
|
作者：
Tauser, Roxana-Georgiana [1 ]
Zugun-Eloae, Florin [2 ]
Jitaru, Daniela [3 ]
Carasevici, Eugen [2 ]
机构：
[1] Gr T Popa Univ Med & Pharm Iasi, Dept Med Chem, Sch Pharm, Iasi 700115, Romania
[2] Gr T Popa Univ Med & Pharm Iasi, Sch Med, Dept Immunol, Iasi 700115, Romania
[3] St Spiridon Univ Emmergency Hosp Iasi, Iasi, Romania
来源：
REVISTA ROMANA DE MEDICINA DE LABORATOR | 2009年 / 16卷 / 03期
关键词：
pharmacogenetics; bevacizumab; hypoxia inducible factor; cancer; CIRCULATING ENDOTHELIAL-CELLS; METASTATIC COLORECTAL-CANCER; BREAST-CANCER; POLYMORPHISMS; ANGIOGENESIS; CHALLENGES; FLUOROURACIL; CHEMOTHERAPY; LEUCOVORIN; GENE;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Pharmacogenetics of innovative angiogenic-targeted monoclonal antibody therapy, yet in its infancy, will be crucial in treatment individualization according to the genetic profile of each patient and molecular features of tumors. Bevacizumab (Avastin) specifically targets the key promotor of angiogenesis - vascular endothelial growth factor (VEGF), whose transcription is critically regulated by hypoxia-inducible factor HIF-1 alpha. The present paper points out the clinical relevance of HIF-1 alpha common genetic polymorphisms to the inter-individual variability in response to anti-VEGF-targeted monoclonal antibody therapeutic regimens, with special reference to colorectal cancer.
引用
收藏
页码：7 / 12
页数：6
相关论文
共 50 条
  • [41] Hypoxia inducible factor 1 (HIF-1) and cardioprotection
    Demet Tekin
    Ali D Dursun
    Lei Xi
    Acta Pharmacologica Sinica, 2010, 31 : 1085 - 1094
  • [42] Hypoxia inducible factor 1 (HIF-1) and cardioprotection
    Tekin, Demet
    Dursun, Ali D.
    Xi, Lei
    ACTA PHARMACOLOGICA SINICA, 2010, 31 (09) : 1085 - 1094
  • [43] Pseudomonas aeruginosa Alkyl Quinolones Repress Hypoxia-Inducible Factor 1 (HIF-1) Signaling through HIF-1α Degradation
    Legendre, Claire
    Reen, F. Jerry
    Mooij, Marlies J.
    McGlacken, Gerard P.
    Adams, Claire
    O'Gara, Fergal
    INFECTION AND IMMUNITY, 2012, 80 (11) : 3985 - 3992
  • [44] Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
    Hu, CJ
    Wang, LY
    Chodosh, LA
    Keith, B
    Simon, MC
    MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (24) : 9361 - 9374
  • [45] The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging
    Leiser, Scott F.
    Kaeberlein, Matt
    BIOLOGICAL CHEMISTRY, 2010, 391 (10) : 1131 - 1137
  • [46] Transport of hypoxia-inducible factor HIF-1α into the nucleus involves importins 4 and 7
    Chachami, Georgia
    Paraskeva, Efrosyni
    Mingot, Jose-Manuel
    Braliou, Georgia G.
    Goerlich, Dirk
    Simos, George
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 390 (02) : 235 - 240
  • [47] Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
    Volm, M
    Koomägi, R
    ANTICANCER RESEARCH, 2000, 20 (3A) : 1527 - 1533
  • [48] Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α
    Haddad, JJ
    Harb, HL
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2005, 5 (03) : 461 - 483
  • [49] Hypoxia-inducible factor (HIF) in crustaceans
    Terwilliger, N.
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2007, 148 : S95 - S95
  • [50] Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD)
    Belibi, Franck
    Zafar, Iram
    Ravichandran, Kameswaran
    Segvic, Anamarija Bauer
    Jani, Alkesh
    Ljubanovic, Danica Galesic
    Edelstein, Charles L.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2011, 300 (05) : F1235 - F1243
12345