The Potential Role of CD44 and CD133 in Colorectal Stem Cell Cancer

被引：11

作者：

Hassan, Wael Abdou ^{[1
]}

Muqresh, Mohamad Ayham ^{[2
]}

Omar, Mohamed ^{[2
]}

机构：

[1] Suleiman Al Rajhi Univ, Coll Med, Dept Basic Sci, Al Bukayriyah, Saudi Arabia

[2] Suleiman Al Rajhi Univ, Coll Med, Al Bukayriyah, Saudi Arabia

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 10期

关键词：

prognosis; therapy; diagnosis; biomarker; cd133; cd44; cancer stem cells; colorectal cancer; COLON-CANCER; EXPRESSION; ADHESION; MARKER;

D O I：

10.7759/cureus.30509

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Colorectal cancer (CRC) is the most preventable malignancy globally, with a high mortality rate. Cancer stem cells (CSCs) are found previously in multiple types of cancer; CRC is one of them, and it has been correlated with several biomarkers. The two most essential markers related to colorectal CSCs are CD44 and CD133, which play a significant role in diagnosis, treatment, and prognosis. Unfortunately, the CSCs with positive CD44 and CD133 biomarkers illustrated an alarming prognosis. Several trials were trying to target those markers to improve the prognosis and cure. We aimed to review the papers that relate to the two markers in terms of diagnosis, treatment, and prognosis.

引用

页数：5

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