Effect of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid on the intraurethral pressure in a rat model of benign prostatic hyperplasia

被引：7

作者：

Choi, Bo Ram ^{[1
,2
,3
]}

Soni, Kiran Kumar ^{[1
,2
,3
]}

Zhang, Li Tao ^{[1
,2
,3
]}

Lee, Sung Won ^{[4
]}

So, Insuk ^{[5
]}

Kim, Hye Kyung ^{[1
,2
,3
]}

Park, Jong Kwan ^{[1
,2
,3
]}

机构：

[1] Chonbuk Natl Univ, Dept Urol, Jeonju 561756, South Korea

[2] Chonbuk Natl Univ, Res Inst Clin Med, Biomed Res Inst, Jeonju 561756, South Korea

[3] Chonbuk Natl Univ, Clin Trial Ctr Med Device, Jeonju 561756, South Korea

[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Urol,Samsung Biomed Res Inst, Seoul, South Korea

[5] Seoul Natl Univ, Coll Med, Dept Physiol & Biomed Sci, Seoul, South Korea

来源：

INTERNATIONAL JOURNAL OF UROLOGY | 2016年 / 23卷 / 03期

关键词：

4-chloro-7-trifluoromethyl-10H-benzo[4; 5]furo[3; 2-b]indole-1-carboxylic acid; benign prostatic hyperplasia; electrostimulation; hypogastric nerve; intraurethral pressure; ALPHA(1A)-ADRENOCEPTOR ANTAGONIST; K+ CHANNEL; TAMSULOSIN; MODULATION; EXPRESSION; CELLS;

D O I：

10.1111/iju.13018

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectivesTo investigate the effect of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid, a new benzofuroindole derivative, on the intraurethral pressure in a rat model of benign prostatic hyperplasia. MethodsBenign prostatic hyperplasia was induced by testosterone and 17-estradiol, which were administered intramuscularly once a day for 12 weeks. The effects of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid and tamsulosin on the intraurethral pressure induced by the electrostimulation of hypogastric nerves after a single intravenous injection of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid (10 mg/kg) or tamsulosin (10 g/kg) were evaluated in a benign prostatic hyperplasia model. The electrostimulation-induced intraurethral pressure was measured just before and after the injection of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid. Bodyweight and genitourinary organ weights were recorded, and serums and tissues were subjected to hormone assays and histopathology. In addition, the expression of 1-adrenoceptors in the prostate was measured by western blotting. ResultsThe benign prostatic hyperplasia groups showed increased prostatic index, increased concentrations of testosterone, free testosterone and estradiol in serum, and increased epithelial thickness of the prostate. An injection of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid or tamsulosin significantly inhibited the elevation of electrostimulation-induced intraurethral pressure. In addition, 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid did not cause a significant change in the blood pressure compared with tamsulosin. While the benign prostatic hyperplasia group showed increased the expression of 1-adrenoceptors, the 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid or tamsulosin injection into a rat model of benign prostatic hyperplasia decreased the expression of 1-adrenoceptors. ConclusionsThese findings show that 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid might be beneficial for lowering the intraurethral pressure associated with benign prostatic hyperplasia, and it could represent a therapeutic option for benign prostatic hyperplasia patients.

引用

页码：259 / 265

页数：7

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