DIASTEREOSELECTIVE SYNTHESIS OF POLY-SUBSTITUTED SYN-IMIDAZOLIDINE-2-THIONES VIA MICROWAVE-ASSISTED THREE-COMPONENT [2+2+1] HETEROCYCLIZATIONS

被引：1

作者：

Hu, Jie-Yu ^{[1
]}

Gao, Yi-Yun ^{[1
]}

Zhang, Wen-Wen ^{[1
]}

Zhang, Ke-Ying ^{[1
]}

Li, Wen-Lian ^{[1
]}

Hao, Wen-Juan ^{[1
]}

Jiang, Bo ^{[1
]}

Li, Guigen ^{[2
,3
]}

机构：

[1] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China

[2] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

[3] Nanjing Univ, Inst Chem & BioMed Sci, Nanjing 210093, Jiangsu, Peoples R China

来源：

HETEROCYCLES | 2019年 / 99卷 / 01期

关键词：

ANTITUMOR EVALUATION; ANTIALLERGIC AGENTS; DERIVATIVES; ANTIFUNGAL; ARYLGLYOXALS; ANTIOXIDANT; STRATEGY; DNA;

D O I：

10.3987/COM-18-S(F)20

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and simple three-component reaction of arylglyoxals, isothiocyanates and arylamines has been developed, delivering poly-substituted syn-imidazolidine-2-thione derivatives with high diastereo- and regioselectivity (up to > 99:1). The microwave-assisted transformation is easy to perform simply by mixing readily available starting materials, thereby featuring mild reaction conditions, bond-forming efficiency and atom-economy.

引用

页码：267 / 278

页数：12

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