Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias

被引：12

作者：

Brendel, J ^{[1
]}

Peukert, S ^{[1
]}

机构：

[1] Aventis Pharma Deutschland GMBH, Med Chem, D-65926 Frankfurt, Germany

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2002年 / 12卷 / 11期

关键词：

arrhythmia; atrial fibrillation; IKur; Kv1.5; potassium channel blockers;

D O I：

10.1517/13543776.12.11.1589

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Atrial arrhythmias are a common problem in cardiological practice. Despite the availability of several antiarrhythmic drugs there is a medical need for safer and more efficient treatments. The voltage-gated potassium channel Kv1.5 is regarded as a promising target for the development of new atrial selective drugs with fewer side effects. This review summarises patents claiming such compounds.-The chemistry and biological data disclosed in these patents are discussed in light of recent work demonstrating the antiarrhythmic effects of Kv1.5 blockers in vivo.

引用

页码：1589 / 1598

页数：10

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