Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias

被引：12
|
作者：
Brendel, J [1 ]
Peukert, S [1 ]
机构：
[1] Aventis Pharma Deutschland GMBH, Med Chem, D-65926 Frankfurt, Germany
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2002年 / 12卷 / 11期
关键词：
arrhythmia; atrial fibrillation; IKur; Kv1.5; potassium channel blockers;
D O I：
10.1517/13543776.12.11.1589
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Atrial arrhythmias are a common problem in cardiological practice. Despite the availability of several antiarrhythmic drugs there is a medical need for safer and more efficient treatments. The voltage-gated potassium channel Kv1.5 is regarded as a promising target for the development of new atrial selective drugs with fewer side effects. This review summarises patents claiming such compounds.-The chemistry and biological data disclosed in these patents are discussed in light of recent work demonstrating the antiarrhythmic effects of Kv1.5 blockers in vivo.
引用
收藏
页码：1589 / 1598
页数：10
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