The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35)

被引：55

作者：

Liu, Dong ^{[1
,2
]}

Niu, Zhong-Xiang ^{[1
]}

机构：

[1] Shanxi Agr Univ, Coll Anim Sci & Vet Med, Tai An, Shandong, Peoples R China

[2] Jinan Anim Husb & Vet Bur, Jinan, Peoples R China

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2009年 / 31卷 / 04期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; MANNAN-BINDING LECTIN; C-REACTIVE PROTEIN; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; MEDIATES INHIBITORY SIGNALS; FOLLICULAR DENDRITIC CELLS; IGG IMMUNE-COMPLEXES; BLOOD-GROUP ANTIGENS; T-DEPENDENT ANTIGEN; C3B C4B RECEPTOR;

D O I：

10.3109/08923970902845768

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system is comprised of soluble and cell surface associated proteins that recognize exogenous, altered, or potentially harmful endogenous ligands. In recent years, the complement system-particularly component C3 and its receptors-have been demonstrated to be a key link between innate and adaptive immunity. Complement receptor type 1 (CR1), the receptor for C3b/C4bcomplement peptides, has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. In this review, we wish to briefly bring forth the structure, genetic polymorphisms, expression and biological functions of CR1.</.

引用

页码：524 / 535

页数：12

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