Multi-scale modelling in computational biomedicine

被引：52
|
作者：
Sloot, Peter M. A. [1 ]
Hoekstra, Alfons G. [1 ]
机构：
[1] Univ Amsterdam, Fac Sci, NL-1098 SJ Amsterdam, Netherlands
来源：
BRIEFINGS IN BIOINFORMATICS | 2010年 / 11卷 / 01期
关键词：
computational biology; multi-scale modelling; molecular dynamics; cellular automata; complex networks; CELLULAR-AUTOMATA; HIV-1; SYSTEMS; SCALE; SIMULATION; CHALLENGES; PREDICTION; NETWORKS; BIOLOGY; HEART;
D O I：
10.1093/bib/bbp038
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The inherent complexity of biomedical systems is well recognized; they are multi-scale, multi-science systems, bridging a wide range of temporal and spatial scales. This article reviews the currently emerging field of multi-scale modelling in computational biomedicine. Many exciting multi-scale models exist or are under development. However, an underpinning multi-scale modelling methodology seems to be missing. We propose a direction that complements the classic dynamical systems approach and introduce two distinct case studies, transmission of resistance in human immunodeficiency virus spreading and in-stent restenosis in coronary artery disease.
引用
收藏
页码：142 / 152
页数：11
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