Multi-scale modelling in computational biomedicine

被引：52

作者：

Sloot, Peter M. A. ^{[1
]}

Hoekstra, Alfons G. ^{[1
]}

机构：

[1] Univ Amsterdam, Fac Sci, NL-1098 SJ Amsterdam, Netherlands

来源：

BRIEFINGS IN BIOINFORMATICS | 2010年 / 11卷 / 01期

关键词：

computational biology; multi-scale modelling; molecular dynamics; cellular automata; complex networks; CELLULAR-AUTOMATA; HIV-1; SYSTEMS; SCALE; SIMULATION; CHALLENGES; PREDICTION; NETWORKS; BIOLOGY; HEART;

D O I：

10.1093/bib/bbp038

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The inherent complexity of biomedical systems is well recognized; they are multi-scale, multi-science systems, bridging a wide range of temporal and spatial scales. This article reviews the currently emerging field of multi-scale modelling in computational biomedicine. Many exciting multi-scale models exist or are under development. However, an underpinning multi-scale modelling methodology seems to be missing. We propose a direction that complements the classic dynamical systems approach and introduce two distinct case studies, transmission of resistance in human immunodeficiency virus spreading and in-stent restenosis in coronary artery disease.

引用

页码：142 / 152

页数：11

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