Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver

被引：12

作者：

Greiser, Julia ^{[1
]}

Weigand, Wolfgang ^{[2
]}

Freesmeyer, Martin ^{[1
]}

机构：

[1] Univ Hosp Jena, Clin Nucl Med, Klinikum 1, D-07747 Jena, Germany

[2] Friedrich Schiller Univ, Inst Inorgan & Analyt Chem, Humboldtstr 8, D-07743 Jena, Germany

来源：

PHARMACEUTICALS | 2019年 / 12卷 / 03期

关键词：

liver; molecular imaging; metals; MRI; SPECT; PET; radiopharmaceuticals; contrast agents; metal complexes; diagnostics; HUMAN SERUM-ALBUMIN; CONTRAST-ENHANCED MRI; GD-EOB-DTPA; NEPHROGENIC SYSTEMIC FIBROSIS; HEPATOCELLULAR-CARCINOMA; ASIALOGLYCOPROTEIN RECEPTOR; IN-VIVO; HEPATOBILIARY SCINTIGRAPHY; GADOLINIUM COMPLEXES; CLINICAL-APPLICATION;

D O I：

10.3390/ph12030137

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver. The main focus was on two established imaging modalities: magnetic resonance imaging (MRI) and nuclear medicine, the latter including scintigraphy and positron emission tomography (PET). The review provides an overview on approved pharmaceuticals like Gd-based CA and Tc-99m-based radiometal complexes, and also on novel agents such as Ga-68-based PET tracers. Metal complexes are presented by their imaging modality, with subsections focusing on their structure and mode of action. Uptake mechanisms, metabolism, and specificity are presented, in context with advantages and limitations of the diagnostic application and taking into account the respective imaging technique.

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页数：28

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