Studies on the methylation status of CpG sequences located in promoters of selected tumor suppressor genes in breast cancer cells

被引：8
|
作者：
Fabianowska-Majewska, K.
Kordek, R.
Krawczyk, B.
机构：
[1] Med Univ Lodz, Dept Biomed Chem, PL-92215 Lodz, Poland
[2] Med Univ Lodz, Dept Pathol, PL-92215 Lodz, Poland
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2006年 / 25卷 / 9-11期
关键词：
hypermethylation of gene promoter; breast cancer;
D O I：
10.1080/15257770600890640
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the tested samples of sporadic breast cancer (100 cases), hypermethylation of CpG sequences located in ER alpha promoter was observed in 62 cases. It correlated with: (i) deficiency of ER alpha protein in 45%, (ii) hypermethylation of BRCA1 promoter in 95%, and (iii) nonmethylated E-cadherin promoter in 90%. Fifty-eight percent of the patients with nonmethylated E-cadherin promoter (56 cases) did not show metastasis to lymphatic nodes. The analysis of the methylation level of the promoter of ER alpha, BRCA1, and E-cadherin, frequently connected with their activity, shows that it can be an important parameter in the diagnosis and therapeutic strategies in sporadic breast cancer.
引用
收藏
页码：1025 / 1028
页数：4
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