Discordance in Nuchal Translucency Measurements in Monochorionic Diamniotic Twins as Predictor of Twin-to-Twin Transfusion Syndrome

被引：23
|
作者：
Linskens, Ingeborg H. [1 ]
de Mooij, Yolanda M. [1 ]
Twisk, Jos W. [2 ]
Kist, Willem J. [3 ]
Oepkes, Dick [3 ]
van Vugt, John M. [1 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Obstet & Gynaecol, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Dept Clin Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands
[3] Leiden Univ, Med Ctr, Dept Obstet, NL-2300 RA Leiden, Netherlands
来源：
TWIN RESEARCH AND HUMAN GENETICS | 2009年 / 12卷 / 06期
关键词：
monochorionic diamniotic twin pregnacies; nuchal translucency; Twin-to-Twin Transfusion Syndrome; TURNER-SYNDROME; LASER-SURGERY; PREGNANCIES; GESTATION; THICKNESS; DIAGNOSIS; TRISOMY-21; KARYOTYPE; DEFECTS;
D O I：
10.1375/twin.12.6.605
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Objective: Discordance in nuchal translucency measurements in monochorionic diamniotic twin pregnancies was assessed as predictor of Twin-to-Twin Transfusion Syndrome. Study Design: A total of 61 monochorionic diamniotic twins were enrolled. Nuchal translucency (NT) and crown-rump-length (CRL) discordance was calculated as the percentage of delta NT and CRL (absolute difference NT/CRL fetus 1 and fetus 2) of the largest measurement, and correlated with subsequent development of Twin-to-Twin Transfusion Syndrome. Results: Twin-to-Twin Transfusion Syndrome developed in 14/61 (23%) of cases. A NT discordance of 20% or more best predicted Twin-to-Twin Transfusion Syndrome development, with a sensitivity of 64% and a specificity of 78%. We found a positive predictive value of 50% and negative predicted value of 86% for Twin-to-Twin Transfusion Syndrome development if NT discordance was 20% or more. Conclusion: NT discordance of more than 20% in monochorionic diamniotic twins is associated with an increased risk for subsequent development of Twin-to-Twin Transfusion Syndrome, and with earlier presentation of symptoms.
引用
收藏
页码：605 / 610
页数：6
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