Cs2CO3-catalyzed alkylation of indoles with trifluoromethyl ketones

被引：10
|
作者：
Liu, Xiao-Dong [1 ]
Wang, Yi [2 ]
Ma, Hai-Yan [1 ]
Xing, Chun-Hui [3 ]
Yuan, Yu [2 ]
Lu, Long [3 ]
机构：
[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China
[2] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON | 2017年 / 73卷 / 16期
基金：
中国国家自然科学基金;
关键词：
3-Indolylmethanol; Trifluoromethyl ketone; Indole; Cesium carbonate; Alkylation; NONREARRANGED MONOTERPENOID UNIT; CATALYZED DIRECT ARYLATION; FRIEDEL-CRAFTS REACTIONS; DIELS-ALDER REACTIONS; ORGANOCATALYTIC HYDROXYALKYLATION; ULTRASONIC-IRRADIATION; EFFICIENT SYNTHESIS; CINCHONA ALKALOIDS; 3-INDOLYLMETHANOLS; ALDEHYDES;
D O I：
10.1016/j.tet.2017.03.012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Cs2CO3-catalyzed alkylation reaction of indoles with trifluoromethyl ketones was presented. Both alicyclic and aromatic trifluoromethyl ketones as well as various substituted indoles are compatible with the methodology. Good to excellent yields of the corresponding trifluoromethyl substituted tertiary alcohols 2,2,2-tritrifluoro-1-(1H-indol-3-yl)-ethan-1-ols were acquired as the sole products. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2283 / 2289
页数：7
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