Dolominol a and B, two new neolignans from Dolomiaea souliei (Franch.) C.Shih

被引：2
|
作者：
Yi, Man [1 ]
Meng, Fan-Cheng [1 ]
Qu, Shen-Yue [1 ]
Mao, Jing-Xin [1 ]
Wang, Guowei [1 ]
Liu, Mingxing [1 ]
Liao, Zhi-Hua [2 ]
Chen, Min [1 ]
机构：
[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing, Peoples R China
[2] Southwest Univ, Sch Life Sci, Chongqing, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 15期
基金：
中国博士后科学基金;
关键词：
Dolomiaea souliei (Franch.) C.Shih; neolignans; dolominol A; dolominol B; hepatoprotective effect;
D O I：
10.1080/14786419.2021.1897125
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new neolignans, dolominol A (1) and dolominol B (2), together with 12 known lignans, erythro-(7S,8R)-guaiacyl-glycerol-beta-O-4 '-dihydroconiferyl ether (3), threo-(7R, 8R)-1- (4- hydroxy- 3- methoxyphenyl) - 2-{4-[(E)- 3- hydroxy- 1- propen yl) ]- 2- methoxyphenoxy}-1, 3- propanediol (4), (-)-dihydrodehydrodiconiferyl alcohol (5), (-)-massoniresinol (6), vladinol D (7), syringaresinol (8), prinsepiol (9), medioresinol (10), (+)-pinoresinol (11), 2 alpha-guaicyl-4-oxo-6 alpha-catechyl-3,7-dioxabicyclo [3.3.0]octane (12), cycloolivil (13), isolariciresinol (14) were isolated from Dolomiaea souliei (Franch.) C.Shih. Their structures were determined by UV, CD, HR-ESI-TOFMS, 1 D and 2 D NMR experiments. Their hepatoprotective effect against LPS-induced L-02 cells injury was also studied. Result revealed that compound 4 showed best protective effect on LPS-induced L-02 cells. [GRAPHICS] .
引用
收藏
页码：3909 / 3916
页数：8
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