Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives

被引：7
|
作者：
Yousif, M. N. M. [1 ]
Nassar, I. F. [2 ]
Yousif, N. M. [1 ]
Awad, H. M. [3 ]
El-Sayed, W. A. [1 ,4 ]
机构：
[1] Natl Res Ctr, Photochem Dept, Cairo, Egypt
[2] Ain Shams Univ, Fac Specif Educ, Cairo, Egypt
[3] Natl Res Ctr, Tanning Mat & Leather Technol Dept, Cairo, Egypt
[4] Qassim Univ, Fac Sci, Chem Dept, Buraydah, Saudi Arabia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 08期
关键词：
piperidinone; pyrimidine; thiazolopyrimidine; diazipine; oxatriazine; thiazole; anticancer; HCT-116; MCF-7; THIOGLYCOSIDES; PYRIDINE; AMINES; ALPHA;
D O I：
10.1134/S1070363219080218
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.
引用
收藏
页码：1673 / 1682
页数：10
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