Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives

被引：7

作者：

Yousif, M. N. M. ^{[1
]}

Nassar, I. F. ^{[2
]}

Yousif, N. M. ^{[1
]}

Awad, H. M. ^{[3
]}

El-Sayed, W. A. ^{[1
,4
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Cairo, Egypt

[2] Ain Shams Univ, Fac Specif Educ, Cairo, Egypt

[3] Natl Res Ctr, Tanning Mat & Leather Technol Dept, Cairo, Egypt

[4] Qassim Univ, Fac Sci, Chem Dept, Buraydah, Saudi Arabia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 08期

关键词：

piperidinone; pyrimidine; thiazolopyrimidine; diazipine; oxatriazine; thiazole; anticancer; HCT-116; MCF-7; THIOGLYCOSIDES; PYRIDINE; AMINES; ALPHA;

D O I：

10.1134/S1070363219080218

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.

引用

页码：1673 / 1682

页数：10

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