Detection of the calcium antagonist nicardipine and its metabolites by gas chromatography-mass spectrometry

被引：6
|
作者：
Ikegaya, H [1 ]
Kobayashi, M [1 ]
Sakurada, K [1 ]
Takeichi, H [1 ]
Yoshida, K [1 ]
Iwase, H [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Forens Med, Bunkyo Ku, Tokyo 1130033, Japan
来源：
FORENSIC SCIENCE INTERNATIONAL | 2002年 / 130卷 / 01期
关键词：
nicardipine; pyridine metabolite; cerebrovascular disease;
D O I：
10.1016/S0379-0738(02)00300-6
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
An 89-year-old male patient, hospitalized with Parkinson's syndrome, suddenly died shortly after an intravenous drug injection. The conditions indicated that an overdose of nicardipine (1.3 mg/(ml kg)) may be given to the patient. At the autopsy, no pathological changes were noted. With a capillary gas chromatograph with mass spectrometer (GC-MS), nicardipine (4.97 mug/ml) and its pyridine metabolite (M-5, 5.0 mug/ml) were detected in the heart blood of the deceased. This result indicated that an overdose of intravenous nicardipine caused a sudden death of a patient in a poor condition. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：25 / 28
页数：4
相关论文
共 50 条
  • [1] Detection of afobazole and its major metabolites using capillary gas chromatography-mass spectrometry
    Bochkov P.O.
    Revel'skii A.I.
    Gulyaev I.V.
    Blynskaya E.V.
    Moscow University Chemistry Bulletin, 2013, 68 (3) : 159 - 166
  • [2] The determination of nandrolone and its metabolites in urine by gas chromatography-mass spectrometry
    Durişehvar Özer
    Aytekin Temìzer
    European Journal of Drug Metabolism and Pharmacokinetics, 1997, 22 (4) : 421 - 425
  • [3] ANALYSIS OF SILABOLINE AND METABOLITES BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY
    SEMENOV, VA
    BLESHINSKAYA, AS
    POMOCHILINA, GN
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1988, 22 (04): : 499 - 501
  • [4] IDENTIFICATION OF METABOLITES OF PHENCYCLIDINE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY
    ADDISON, JB
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1981, 15 (03): : 110 - 113
  • [5] Detection of several classes of pesticides and metabolites in meconium by gas chromatography-mass spectrometry
    Bielawski, D
    Ostrea, E
    Posecion, N
    Corrion, M
    Seagraves, J
    CHROMATOGRAPHIA, 2005, 62 (11-12) : 623 - 629
  • [6] Detection of Several Classes of Pesticides and Metabolites in Meconium by Gas Chromatography-Mass Spectrometry
    D. Bielawski
    E. Ostrea
    N. Posecion
    M. Corrion
    J. Seagraves
    Chromatographia, 2005, 62 : 623 - 629
  • [7] Issues pertaining to the analysis of buprenorphine and its metabolites by gas chromatography-mass spectrometry
    Wang, Yu-Shan
    Lin, Dong-Liang
    Yang, Shu-Ching
    Wu, Meng-Yan
    Liu, Ray H.
    Su, Lien-Wen
    Cheng, Pai-Sheng
    Liu, Chiareiy
    Fuh, Ming-Ren
    JOURNAL OF CHROMATOGRAPHY A, 2010, 1217 (10) : 1688 - 1694
  • [8] Detection and identification of carprofen and its in vivo metabolites in greyhound urine by capillary gas chromatography-mass spectrometry
    Dumasia, MC
    Ginn, A
    Hyde, W
    Peterson, J
    Houghton, E
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 788 (02): : 297 - 307
  • [9] Determination of zolpidem and its metabolites by chromatography-mass spectrometry
    E. A. Krylova
    S. S. Kataev
    Yu. A. Khomov
    Journal of Analytical Chemistry, 2013, 68 : 722 - 729
  • [10] Determination of zolpidem and its metabolites by chromatography-mass spectrometry
    Krylova, E. A.
    Kataev, S. S.
    Khomov, Yu. A.
    JOURNAL OF ANALYTICAL CHEMISTRY, 2013, 68 (08) : 722 - 729
12345