Evaluating the impact of x-ray spectral shape on image quality in flat-panel CT breast imaging

In recent years, there has been an increasing interest in exploring the feasibility of dedicated computed tomography (CT) breast imaging using a flat-panel digital detector in a truncated cone-beam imaging, geometry. Preliminary results are promising and it appears as if three-dimensional tomographic imaging of the breast has great potential for reducing the masking effect of superimposed parenchymal structure typically observed with conventional mammography. In this study, a mathematical framework used for determining optimal design and acquisition parameters for such a CT breast imaging system is described. The ideal observer signal-to-noise ratio (SNR) is used as a figure of merit, under the assumptions that the imaging system is linear and shift invariant. Computation of the ideal observer SNR used a parallel-cascade model to predict signal and noise propagation through the detector, as well as a realistic model of the lesion detection task in breast imaging. For all evaluations, the total mean glandular dose for a CT breast imaging study was constrained to be approximately equivalent to that of a two-view conventional mammography study. The framework presented was used to explore the effect of x-ray spectral shape across an extensive ran-e of kVp settings, filter material types, and filter thicknesses. The results give an indication of how spectral shape can affect image quality in flat-panel CT breast imaging. (c) 2007 American Association of Physicists in Medicine.