AMG 176 exhibits robust antitumor activity in combination with standard of care agents in models of acute myeloid leukemia

被引：0
|
作者：
Caenepeel, Sean [1 ]
Belmontes, Brian [1 ]
Osgood, Tao [1 ]
Cajulis, Elaina [1 ]
Coxon, Angela [1 ]
Canon, Jude [1 ]
Hughes, Paul E. [1 ]
机构：
[1] Amgen Inc, Thousand Oaks, CA USA
来源：
CANCER RESEARCH | 2019年 / 79卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2019-2180
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2180
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Venetoclax Dosing in Combination with Antifungal Agents: Real World Experience in Patients with Acute Myeloid Leukemia
    Rausch, Caitlin R.
    DiNardo, Courtney D.
    Maiti, Abhishek
    Jammal, Nadya
    Kadia, Tapan M.
    Marx, Kayleigh
    Borthakur, Gautam M.
    Savoy, J. Michael
    Pemmaraju, Naveen
    Dipippo, Adam
    Daver, Naval G.
    Chew, Serena
    Sasaki, Koji
    Issa, Ghayas C.
    Naqvi, Kiran
    Ravandi, Farhad
    Kantarjian, Hagop M.
    Konopleva, Marina Y.
    BLOOD, 2019, 134
  • [42] Efficacy of topoisomerase I and II inhibitors in combination with standard chemotherapeutic agents (Ara-C and daunorubicin) in the management of acute myeloid leukemia (AML).
    Saba, HI
    Sullivan, DM
    Loughran, TP
    Moscinski, LC
    Sullivan, PA
    Morelli, GA
    BLOOD, 2003, 102 (11) : 261B - 261B
  • [43] The differentiated CD47 monoclonal antibody AO-176 exhibits significant in vivo activity against xenograft models of pediatric acute lymphoblastic leukemia (ALL).
    Lock, Richard B.
    Evans, Kathryn
    El-Zein, Narimanne
    Earley, Eric J.
    Erickson, Stephen W.
    Teicher, Beverly A.
    Sung, Victoria
    Smith, Malcolm A.
    CANCER RESEARCH, 2021, 81 (13)
  • [44] Antitumor synergy with SY-1425, a selective RARα agonist, and hypomethylating agents in retinoic acid receptor pathway activated models of acute myeloid leukemia
    McKeown, Michael R.
    Johannessen, Liv
    Lee, Emily
    Fiore, Christopher
    di Tomaso, Emmanuelle
    HAEMATOLOGICA, 2019, 104 (04) : E138 - E142
  • [45] The MDM2 inhibitor AMG 232 causes tumor regression and potentiates the anti-tumor activity of MEK inhibition and DNA-damaging cytotoxic agents in preclinical models of acute myeloid leukemia
    Canon, Jude R.
    Osgood, Tao
    Saiki, Anne Y.
    Oliner, Jonathan D.
    CANCER RESEARCH, 2016, 76
  • [46] ACTIVITY OF IAP ANTAGONIST DEBIO 1143 AS A MONOTHERAPY AND IN COMBINATION WITH STANDARD OF CARE AGENTS IN MODELS OF HUMAN LUNG CANCER OF DIFFERENT HISTOTYPES
    Wiedemann, N.
    Langdon, C. G.
    Held, M. A.
    Platt, J. T.
    Zanna, C.
    Sorensen, M.
    Wang, S.
    Bosenberg, M. W.
    Stern, D. F.
    Vuagniaux, G.
    JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (04) : S21 - S21
  • [47] Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia
    Gopalakrishnapillai, Anilkumar
    Kolb, E. Anders
    McCahan, Suzanne M.
    Barwe, Sonali P.
    LEUKEMIA RESEARCH, 2017, 58 : 91 - 97
  • [48] Combination of epigenetic modifiers achieves complete remission in xenograft models of pediatric acute myeloid leukemia
    Gopalakrishnapillai, Anilkumar
    Kolb, E. Anders
    Barwe, Sonali P.
    CANCER RESEARCH, 2015, 75
  • [49] Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo
    Kosciuczuk, Ewa M.
    Saleiro, Diana
    Kroczynska, Barbara
    Beauchamp, Elspeth M.
    Eckerdt, Frank
    Blyth, Gavin T.
    Abedin, Sameem M.
    Giles, Francis J.
    Altman, Jessica K.
    Platanias, Leonidas C.
    BLOOD, 2016, 128 (03) : 410 - 414
  • [50] Moojecin: The first disintegrin from Bothrops moojeni venom and its antitumor activity in acute myeloid leukemia
    Almeida, Gabriela de Oliveira
    Cintra, Adélia Cristina Oliveira
    Silva, Thiago Abrahão
    de Oliveira, Isadora Sousa
    Correia, Lucas Ian Veloso
    Torquato, Ricardo José Soares
    Ferreira Junior, Rui Seabra
    Arantes, Eliane Candiani
    Sampaio, Suely Vilela
    International Journal of Biological Macromolecules, 2024, 279
12345