Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones

被引：54
|
作者：
Hussain, Tanvir [1 ]
Siddiqui, Hamid Latif [1 ]
Zia-ur-Rehman, Muhammad [2 ]
Yasinzai, Muhammad Masoom [3 ]
Parvez, Masood [4 ]
机构：
[1] Univ Punjab, Inst Chem, Lahore 54590, Pakistan
[2] Pakistan Council Sci & Ind Res, Appl Chem Res Ctr, Lahore 54600, Pakistan
[3] Univ Balochistan, Inst Biochem, Quetta, Pakistan
[4] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 11期
关键词：
Imidazole; Chalcones; Anti-oxidant; Anti-fungal; Anti-leishmanial; CHALCONES; INHIBITORS; DESIGN; DERIVATIVES; CRYSTAL;
D O I：
10.1016/j.ejmech.2009.06.038
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：4654 / 4660
页数：7
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